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ChemicalBook > Product Catalog >Organic Chemistry >Hydrocarbons and derivatives >Hydrocarbon halides >1-Fluoronaphthalene

1-Fluoronaphthalene

1-Fluoronaphthalene Structure
CAS No.
321-38-0
Chemical Name:
1-Fluoronaphthalene
Synonyms
Fluoronaphthalene;1-FLUORONAPTHALENE;1-Fluornaftalen;48720-u;NSC 4690;uoronaphthaL;Duloxetine-8;1-Fluoronaphth;Fluorophthalene;Duloxetine Imp-G
CBNumber:
CB8219439
Molecular Formula:
C10H7F
Molecular Weight:
146.16
MOL File:
321-38-0.mol
MSDS File:
SDS
Modify Date:
2024/7/24 17:31:20
Request For Quotation

1-Fluoronaphthalene Properties

Melting point -13 °C (lit.)
Boiling point 215 °C (lit.)
Density 1.1322 g/mL at 20 °C (lit.)
refractive index n20/D 1.593(lit.)
Flash point 150 °F
storage temp. Sealed in dry,Room Temperature
solubility slightly soluble in water, well soluble in chloroform, ethyl acetate, and methanol.
form Oil
color Colourless to Yellow
Specific Gravity 1.332
Water Solubility Not miscible or difficult to mix in water.
BRN 1906413
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey CWLKTJOTWITYSI-UHFFFAOYSA-N
CAS DataBase Reference 321-38-0(CAS DataBase Reference)
NIST Chemistry Reference Naphthalene, 1-fluoro-(321-38-0)
EPA Substance Registry System 1-Fluoronaphthalene (321-38-0)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  UN2810
WGK Germany  3
RTECS  QJ7100000
Hazard Note  Flammable
TSCA  T
HazardClass  IRRITANT
HS Code  29039990
NFPA 704
2
1 0

1-Fluoronaphthalene price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 196657 1-Fluoronaphthalene 99% 321-38-0 5G ₹2574.2 2022-06-14 Buy
Sigma-Aldrich(India) 196657 1-Fluoronaphthalene 99% 321-38-0 25G ₹9442.25 2022-06-14 Buy
ALFA India ALF-A18378-22 1-Fluoronaphthalene, 98% 321-38-0 100g ₹29155 2022-05-26 Buy
TCI Chemicals (India) F0212 1-Fluoronaphthalene min. 98.0 % 321-38-0 5G ₹2700 2022-05-26 Buy
TCI Chemicals (India) F0212 1-Fluoronaphthalene min. 98.0 % 321-38-0 25G ₹6900 2022-05-26 Buy
Product number Packaging Price Buy
196657 5G ₹2574.2 Buy
196657 25G ₹9442.25 Buy
ALF-A18378-22 100g ₹29155 Buy
F0212 5G ₹2700 Buy
F0212 25G ₹6900 Buy

1-Fluoronaphthalene Chemical Properties,Uses,Production

Chemical Properties

clear slightly yellow to yellow-brown liquid

Uses

1-Fluoronaphthalene is a fluorinated naphthalene derivative that is metabolized by fungal monooxygenase-epoxide hydrolase. It is also used as a pharmaceutical intermediate. It is Duloxetine impurity.

Application

1-Fluoronaphthalene was used in t-BuLi-mediated synthesis of 6-substituted phenanthridines. It was also used in the synthesis of LY248686, a potent inhibitor of serotonin and norepinephrine uptake.

Preparation

The preparation of 1-Fluoronaphthalene is as follows:1) Diazotization reaction: 1500 g of hydrochloric acid (mass concentration: 25%) and 300 g of naphthylamine were added to a 3000 mL three-necked flask, stirred and heated to 75 ° C to dissolve, and the temperature was lowered to below 5 ° C, and 148 g was slowly added at this temperature. Sodium nitrite, stirred at low temperature for 0.3 hours after the addition, to obtain a diazonium salt solution;2) Substitution reaction: 360 g of fluoroboric acid solution (concentration: 45%) was added to the resulting solution obtained in the step 1), stirred for 0.25 h, filtered, and the filter cake was dried at a temperature of 50 ° C for 0.2 h to obtain Dry naphthylamine diazonium salt fluoroborate double salt;3) Hot air decomposition: the dried diazonium salt fluoroborate double salt is slowly added to the reactor through which hot air (hot air temperature is 85-90 ° C), and the dried powdered naphthylamine diazonium salt fluoroborate double salt is The hot air blows up the dispersion and absorbs the heat for thermal decomposition to obtain a 1-fluoronaphthalene solution containing a small amount of solid impurities;4) Purification treatment: the 1-fluoronaphthalene solution obtained in the step 3) is first washed with pure water for 3 to 6 times, then neutralized with a soda ash to a pH of 6.8 to 7.2, and finally the oil layer is separated by filtration, and the filtrate is taken. The distillation treatment gave 210 g of a naphthalene-based fluorine-containing intermediate 1-fluoronaphthalene in an amount of 99.8%.

321-38-0.png

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Simple aromatic halogenated organic compounds, such as Fluoronaphthalene, are very unreactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

1-Fluoronaphthalene Preparation Products And Raw materials

Raw materials

Preparation Products

4-Fluoronaphtalene-1-boronic acid 2-(1-FLUORONAPHTHALEN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE (R)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine Duloxetine 3-Bromo-1-fluoronaphthalene
(S)-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine 2-(1-NAPHTHYLENE)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 1-fluoro-2-iodonaphthalene 4-FLUORONAPHTHALENE-1-SULFONYL CHLORIDE (S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1)
3-Bromo-1-fluoro-2-iodonaphthalene (S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1) Duloxetine Impurity 4
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1-Fluoronaphthalene Suppliers

Global( 673)Suppliers
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GLR Innovations +91 9891111994 New Delhi, India 4542 58 Inquiry
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Vibrant Life Sciences +917989177519 Telangana, India 26 58 Inquiry
Supplier Advantage
GLR Innovations 58
ULTIMA CHEMICALS 58
TRC FINE CHEMS 58
Chemicea Pharmaceuticals Pvt Ltd 58
SNECOFRi Pvt Ltd 58
WARUKSHA LABORATORIES PVT LTD 58
Sagar Speciality Chemicals Private Limited 58
JSK Chemicals 58
Varanous Labs Pvt Ltd 58
Vibrant Life Sciences 58

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1-Fluoronaphthalene Spectrum

1-Fluoronaphthalene(321-38-0)MS1-Fluoronaphthalene(321-38-0)1HNMR1-Fluoronaphthalene(321-38-0)13CNMR1-Fluoronaphthalene(321-38-0)IR11-Fluoronaphthalene(321-38-0)Raman

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1-Fluoronaphth Duloxetine Hydrochloride impurity G 1-FLUORONAFTALENO Fluorophthalene alpha-Fluoronaphthalene 1-FLUORONAPHTHALENE 1-FLUORONAPHTHALENE, 1000MG, NEAT I-Fluoronaphthalene 1-Fluoronaphthalene99% I-Fluornaphthalin 1-Fluoronaphthalene,98% 1-Fluoronaphthalene solution 48720-u 1-fluoro-naphthalen NSC 4690 α-fluorinated naphthalene Duloxetine USP IMpurity G naphthyl fluoride C10H7F, α Duloxetine EP IMpurity G 1 - fluorinated naphthalene Naphthalene,1-fluoro- 1-Fluoronaphthalene, 97+% 1-fluoromaphthalene 1-Fluoronaphthalene 99.5% low price 1-Fluoronaphthalene 321-38-0 Duloxetine Impurity 13 uoronaphthaL Duloxetine EP Impurity G (USP RC G) 1-FLUORONAPHTHALENE NEAT low price 1-Fluoronaphthalene Duloxetine impurity G Duloxetine-8 1-fluoronaphthlene 1-Fluoronaphthalene@2.0 mg/mL in Dichloromethane 1-Fluoronaphthalene@0.2 mg/mL in CH2Cl2 1-Fluoronaphthalene @0.1 mg/mL in Acetone 2-Fluorobiphenyl & 1-Fluoronaphthalene@2.0 mg/mL in CH2Cl2 1-FluoronaphthaleneSolution,1,000mg/L,1mL 1-Fluornaphthalin Duloxetine EP Impurity G (α-fluonaphthalene) 1 - fluorinated naphthalene Finn 1-fluoronaphthalene(For export only) 1-Fluoronaphthalene ISO 9001：2015 REACH α-Fluoronaphthalene 1-Fluoronaphthalene (Duloxetine Impurity) Duloxetine Imp-G Duloxetine Impurity58 1-FLUORONAPTHALENE Fluoronaphthalene 1-Fluornaftalen Duloxetine Impurity 13(Duloxetine EP Impurity G) Duloxetine Hydrochloride EP Impurity G 1-Fluorinaphthalene 321-38-0 321-18-0 C10H7F FC10H7