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4-Methylpyrazole

4-Methylpyrazole Structure
CAS No.
7554-65-6
Chemical Name:
4-Methylpyrazole
Synonyms
FOMEPIZOLE;4-Methyl-1H-pyrazole;Antizol;fomepizol;Antizol-Vet;AKOS B014452;Antizol (TN);4-Fomepizole;4-Methylpyrazol;4-methyl-pyrazol
CBNumber:
CB8233079
Molecular Formula:
C4H6N2
Molecular Weight:
82.1
MOL File:
7554-65-6.mol
MSDS File:
SDS
Modify Date:
2023/5/25 18:01:19
Request For Quotation

4-Methylpyrazole Properties

Melting point 13°C
Boiling point 99-100 °C6 mm Hg(lit.)
Density 0.993 g/mL at 25 °C(lit.)
vapor pressure 7.136-87.85Pa at 20-50℃
refractive index n20/D 1.495(lit.)
Flash point 205 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble
form Liquid After Melting
pka 14.95±0.50(Predicted)
Specific Gravity 0.993
color Clear colorless to yellow
Water Solubility soluble
Sensitive Hygroscopic
Merck 14,4226
BRN 105204
LogP 1.097 (est)
CAS DataBase Reference 7554-65-6(CAS DataBase Reference)
NIST Chemistry Reference 4-methylpyrazole(7554-65-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36-24/25
RIDADR  2810
WGK Germany  3
RTECS  UQ7350000
F  10-23
HazardClass  6.1(b)
PackingGroup  III
HS Code  29331990
Toxicity LD50 (7 days) in mice, rats (mmol/kg): 3.8, 3.8 i.v.; 7.8, 6.5 orally (Magnusson)
NFPA 704
0
2 0

4-Methylpyrazole price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 222569 Fomepizole 99% 7554-65-6 1G ₹9250 2022-06-14 Buy
Sigma-Aldrich(India) 222569 Fomepizole 99% 7554-65-6 1G ₹9250 2022-06-14 Buy
Sigma-Aldrich 222569 Fomepizole 99% 7554-65-6 5G ₹17280 2022-06-14 Buy
Sigma-Aldrich(India) 222569 Fomepizole 99% 7554-65-6 5G ₹17280 2022-06-14 Buy
TCI Chemicals (India) M0774 4-Methylpyrazole min. 98.0 % 7554-65-6 1G ₹4900 2022-05-26 Buy
Product number Packaging Price Buy
222569 1G ₹9250 Buy
222569 1G ₹9250 Buy
222569 5G ₹17280 Buy
222569 5G ₹17280 Buy
M0774 1G ₹4900 Buy

4-Methylpyrazole Chemical Properties,Uses,Production

Description

Fomepizole is the first drug indicated as an antidote for ethylene glycol poisoning (it has also shown promise as a treatment for methanol poisoning). Fomepizole is 4-methyl-1H-pyrazole active as a synthetic alcohol dehydrogenase inhibitor, blocking the formation of toxic ethylene glycol metabolites which are responsible for a severe metabolic acidosis and renal failure. In limited human studies, it reversed the toxicity of potentially lethal doses of ethylene glycol. The main urinary metabolite has been reported to be 4-carboxypyrazole by oxidation of the methyl group. Compared with the current treatment (ethanol), the duration of action is longer and the safety is improved, with no toxic effects reported.

Chemical Properties

clear colourless to yellowish liquid after melting

Uses

Fomepizole (4-Methylpyrazole) can be used as:

  • A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst.
  • A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration.
  • A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.

Definition

ChEBI: A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.

General Description

4-Methylpyrazole inhibits CYP2E1 activity. It also acts as alcohol dehydrogenase inhibitor.

4-Methylpyrazole Preparation Products And Raw materials

Raw materials

Sulfuric acid Isobutyraldehyde Sodium iodide Hydrazine hydrate 1,1,3,3-TETRAETHOXY-2-METHYLPROPANE
Methallyl acetate 4-METHYLPYRAZOLE-5-CARBOXYLIC ACID 3-AMINO-2-METHYLACRYLALDEHYDE
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Preparation Products

1H-Pyrazole,4-methyl-1-nitro-(9CI) Antihistamine-1

4-Methylpyrazole Suppliers

Global( 326)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Apothecon Pharmaceuticals Pvt Ltd +91-2662244212 +91-9099007601 Gujarat, India 28 58 Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd. +91-26463395 +91-7926462688 Gujarat, India 1615 58 Inquiry
Global Calcium Pvt Ltd +91-8050750904 +91-8040554500 Karnataka, India 132 58 Inquiry
Gland Pharma Ltd +91-7075736524 +91-9700602423 Telangana, India 44 58 Inquiry
Mylan Laboratories Ltd +91-4023550543 +91-4030866666 Telangana, India 150 58 Inquiry
Apicore Pharmaceuticals Pvt Ltd +91-2662267177 +91-2662267166 Gujarat, India 181 58 Inquiry
Inventys Research Company Pvt Ltd +91-2271400200 +91-9320013358 Mumbai, India 21 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Supplier Advantage
Apothecon Pharmaceuticals Pvt Ltd 58
Rivashaa Agrotech Biopharma Pvt. Ltd. 58
Global Calcium Pvt Ltd 58
Gland Pharma Ltd 58
Mylan Laboratories Ltd 58
Apicore Pharmaceuticals Pvt Ltd 58
Inventys Research Company Pvt Ltd 58
TCI Chemicals (India) Pvt. Ltd. 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58

4-Methylpyrazole Spectrum

4-Methylpyrazole(7554-65-6)1HNMR4-Methylpyrazole(7554-65-6)Raman4-Methylpyrazole(7554-65-6)IR

7554-65-6(4-Methylpyrazole)Related Search:

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Metazachlor 3-Aminopyrazole-4-carboxylic acid 4,5,6,7-TETRAHYDROINDAZOLE Ethyl pyrazole-4-carboxylate 5-AMINO-1-PHENYLPYRAZOLE-4-CARBOXAMIDE
Zolpidem 5-AMINO-4-CYANO-3-CYANOMETHYL-1-PHENYLPYRAZOLE 3-Amino-4-pyrazolecarbonitrile 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE
3-Amino-4-pyrazolecarboxamide hemisulfate ETHYL 3-AMINO-2-METHYLPYRAZOLE-4-CARBOXYLATE 4-METHYLPYRAZOLE HYDROCHLORIDE
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