4-Methylpyrazole
4-Methylpyrazole
- CAS:
- 7554-65-6
- MF:
- C4H6N2
- MW:
- 82.1
Suppliers by country/region
Company Type
Properties
- Melting point:
- 13°C
- Boiling point:
- 99-100 °C6 mm Hg(lit.)
- Density
- 0.993 g/mL at 25 °C(lit.)
- vapor pressure
- 7.136-87.85Pa at 20-50℃
- refractive index
- n
20/D 1.495(lit.)
- Flash point:
- 205 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble
- form
- Liquid After Melting
- pka
- 14.95±0.50(Predicted)
- Specific Gravity
- 0.993
- color
- Clear colorless to yellow
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- Merck
- 14,4226
- BRN
- 105204
- LogP
- 1.097 (est)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36-24/25
- RIDADR
- 2810
- WGK Germany
- 3
- RTECS
- UQ7350000
- F
- 10-23
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29331990
- Toxicity
- LD50 (7 days) in mice, rats (mmol/kg): 3.8, 3.8 i.v.; 7.8, 6.5 orally (Magnusson)
Use
Fomepizole is the first drug indicated as an antidote for ethylene glycol poisoning (it has also shown promise as a treatment for methanol poisoning). Fomepizole is 4-methyl-1H-pyrazole active as a synthetic alcohol dehydrogenase inhibitor, blocking the formation of toxic ethylene glycol metabolites which are responsible for a severe metabolic acidosis and renal failure. In limited human studies, it reversed the toxicity of potentially lethal doses of ethylene glycol. The main urinary metabolite has been reported to be 4-carboxypyrazole by oxidation of the methyl group. Compared with the current treatment (ethanol), the duration of action is longer and the safety is improved, with no toxic effects reported.
9 India supplier list of "4-Methylpyrazole"
- Product Name:Fomepizole
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Fomepizole
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Fomepizole
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:4-Methyl Pyrazole
- Products Intro:Purity: 99.45 | Package: Std Packing
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:Fomepizole
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Fomepizole
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Karnataka,INDIA
- Product Name:Fomepizole
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Fomepizole
- Products Intro:Brand:sigma aldrich | Product Number:222569 | Purity:99%
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Fomepizole
- Products Intro:Brand:synzeal | Product Number:72129137
- Company Type: Trader
- Country/Region: Gujarat,INDIA