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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

CAS No.: 28289-54-5

Chemical Name:: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Synonyms: MPTP;NSC 139654;Naphthoic Acid Impurity 111;1-METHYL-4-PHENYL-PIPERIDINE-3-EN;1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin;1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine;1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin;1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE;1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE;N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE

CBNumber:: CB8254906

Molecular Formula:: C12H15N

Molecular Weight:: 173.25

MOL File:: 28289-54-5.mol

MSDS File:: SDS

Modify Date:: 2026/9/12 18:55:36

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Properties

Melting point	aprox. 36°C
Boiling point	128-132 °C12 mm Hg(lit.)
Density	1.001±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
form	Solid
pka	8.66±0.40(Predicted)
color	Pale Yellow to Light Yellow
Merck	13,6319
Stability	Stable. Incompatible with strong oxidizing agents.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS06
Signal word	Danger
Hazard statements	H370-H301
Precautionary statements	P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501
Hazard Codes	T
Risk Statements	25-39/23/24/25
Safety Statements	45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	UT8358900
HazardClass	6.1(b)
PackingGroup	III
Hazardous Substances Data	28289-54-5(Hazardous Substances Data)
Toxicity	Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine price

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Solid

Uses

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

Definition

ChEBI: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.

Metabolic pathway

N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in a rat pheochromocytoma cell line is oxidized to give the N-methyl-4-phenylpyridinium ion.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Suppliers

Global( 73)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6094	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6053	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6666	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21533	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32997	60	Inquiry
career henan chemical co	+86-0371-86658258	China	29780	58	Inquiry
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	CHINA	21135	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8618071025641	China	23504	58	Inquiry
PT CHEM GROUP LIMITED	+86-85511178; +86-85511178	China	35405	58	Inquiry
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	China	49856	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58

28289-54-5(1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)Related Search:

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MPTP 1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)ochloride NSC 139654 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin 1-METHYL-4-PHENYL-PIPERIDINE-3-EN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE 1-METHYL-4-PHENYL-1,2,3,6-TETRA-*HYDROPY RIDINE FREE N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) C12H15N 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE 28289-54-5 Naphthoic Acid Impurity 111 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (1mg/ml in Acetonitrile) 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine , 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 28289-54-5 8289-54-5 Building Blocks C9 to C46 Heterocyclic Building Blocks Pyridines Neurochemicals Heterocyclic Compounds