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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Pyridine derivatives >1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Structure
CAS No.
28289-54-5
Chemical Name:
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
Synonyms
MPTP;NSC 139654;Naphthoic Acid Impurity 111;1-METHYL-4-PHENYL-PIPERIDINE-3-EN;1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin;1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine;1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin;1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE;1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE;N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE
CBNumber:
CB8254906
Molecular Formula:
C12H15N
Molecular Weight:
173.25
MOL File:
28289-54-5.mol
MSDS File:
SDS
Modify Date:
2023/5/15 10:44:00
Request For Quotation

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Properties

Melting point aprox. 36°C
Boiling point 128-132 °C12 mm Hg(lit.)
Density 1.001±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
form Solid
pka 8.66±0.40(Predicted)
color Pale Yellow to Light Yellow
Merck 13,6319
Stability Stable. Incompatible with strong oxidizing agents.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS06
Signal word  Danger
Hazard statements  H370-H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501
Hazard Codes  T
Risk Statements  25-39/23/24/25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  UT8358900
HazardClass  6.1(b)
PackingGroup  III
Toxicity Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic.

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Solid

Uses

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

Definition

ChEBI: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.

Metabolic pathway

N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in a rat pheochromocytoma cell line is oxidized to give the N-methyl-4-phenylpyridinium ion.

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE Suppliers

Global( 60)Suppliers
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
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CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 58
ANHUI WITOP BIOTECH CO., LTD 58
PT CHEM GROUP LIMITED 58
GIHI CHEMICALS CO.,LIMITED 58

28289-54-5(1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE)Related Search:

3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOL-5-OL HYDROCHLORIDE phenindamine Setiptiline 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Xaliproden hydrochloride
3-[4-(3,6-DIHYDRO-4-PHENYL-1(2H)-PYRIDINYL)BUTYL]-1H-INDOLE-5-CARBOXYLIC ACID HYDROCHLORIDE 1-METHYL-4-(2-METHYLPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE Flupranone 2,3-dihydro-2-methyl-9-phenyl-1H-indeno[2,1-c]pyridine hydrobromide 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
phenindamine tartrate ROXINDOLE MESYLATE METHYL-4-PHENYL 1,2,3,6-TETRAHYDROPYRIDINE, 1-, [METHYL-3H] 2-METHYL-9-PHENYL-2,3,4,9-TETRAHYDRO-1-PYRIDINENE TARTRATE METHYL-4-PHENYL 1,2,3,6-TETRAHYDROPYRIDINE, 1-, [METHYL-14C]
1-phenyl-4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butan-1-one Fenpipalone
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MPTP 1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)ochloride NSC 139654 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin 1-METHYL-4-PHENYL-PIPERIDINE-3-EN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE 1-METHYL-4-PHENYL-1,2,3,6-TETRA-*HYDROPY RIDINE FREE N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) C12H15N 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE 28289-54-5 Naphthoic Acid Impurity 111 28289-54-5 8289-54-5 Building Blocks C9 to C46 Heterocyclic Building Blocks Pyridines Neurochemicals Heterocyclic Compounds