ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Ubiquitin >DUB inhibitors >PR-619
PR-619
- CAS No.
- 2645-32-1
- Chemical Name:
- PR-619
- Synonyms
- PR-619;CS-1128;6-Diamino-3;PR-619;PR619;PR-619, >=98%;PR-619 USP/EP/BP;5-dithiocyanopyridine;PR 619, DUB inhibitor;PR-619, 10 mM in DMSO;2,6-DiaMino-3,5-dithiocyanopyridine
- CBNumber:
- CB82656906
- Molecular Formula:
- C7H5N5S2
- Molecular Weight:
- 223.28
- MOL File:
- 2645-32-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/4/27 16:16:43
| Melting point | 210℃ |
|---|---|
| Boiling point | 406.0±45.0 °C(Predicted) |
| Density | 1.61±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble5mg/mL (clear solution) |
| pka | -0.19±0.50(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H317-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-37/38-41-43 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
PR-619 price More Price(2)
PR-619 Chemical Properties,Uses,Production
Uses
PR-619 has been used:
- as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cells
- as a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transduction
- in radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays
Biochem/physiol Actions
PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.
PR-619 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 155)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29858 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32222 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 22855 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10473 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6391 | 58 | Inquiry |
2645-32-1(PR-619)Related Search:
PR-619
2,6-DiaMino-3,5-dithiocyanopyridine
3,5-dithiocyanatopyridine-2,6-diaMine
Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester
2,6-Diamino-3,5-dithiocyanopyridine PR 619
PR 619 2,6-Diamino-3,5-dithiocyanopyridine
2,6-Diaminopyridine-3,5-bis(thiocyanate)
PR-619;PR619
3,5-Bis-thiocyanato-pyridine-2,6-diamine
PR-619, >=98%
2,6-Diamino-3,5-dithiocyanato-pyridin, 98%
2;6-DIAMINO-3;5-DITHIOCYANOPYRIDINE;PR 619;PR619
5-dithiocyanopyridine
6-Diamino-3
CS-1128
PR-619 USP/EP/BP
(2,6-diamino-5-thiocyanatopyridin-3-yl)thiocyanate
DUBs,tau,G0/G1,Autophagy,PR-619,PR619,Deubiquitinase,ER-stress,ubiquitination,inhibit,Inhibitor,Apoptosis,arrest
PR 619, DUB inhibitor
PR-619, 10 mM in DMSO
2645-32-1
Inhibitors