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FOSTRIECIN SODIUM SALT

CAS No.: 87860-39-7

Chemical Name:: FOSTRIECIN SODIUM SALT

Synonyms: FST;CL-920;FST344;FOSTRIECIN;PHOSPHOTRIENIN;ci920sodiumsalt;cl1565asodiumsalt;FOSTRIECIN SODIUM;FOSTRIECIN SODIUM SALT;antibioticci920sodiumsalt

CBNumber:: CB8295127

Molecular Formula:: C19H28NaO9P

Molecular Weight:: 454.39

MOL File:: 87860-39-7.mol

MSDS File:: SDS

Modify Date:: 2024/4/25 17:59:01

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FOSTRIECIN SODIUM SALT Properties

storage temp.	-20°C
solubility	Soluble in H2O
form	Colorless solid
Water Solubility	Soluble to 100 mM in water
InChIKey	GMNLFZGMQHSFFV-DSXPUHJBNA-N
SMILES	[C@@H](OP(O)(O)=O)(C[C@@H](O)/C=C\C=C/C=C/CO)[C@@](O)(C)/C=C/[C@H]1CC=CC(=O)O1.[NaH] \|&1:0,7,17,22,r\|

SAFETY

Risk and Safety Statements

Hazard statements	H402
Precautionary statements	P273-P501
WGK Germany	3
RTECS	UQ0600000

FOSTRIECIN SODIUM SALT price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	F4425	Fostriecin sodium salt from Streptomyces pulveraceus ≥98% (HPLC)	87860-39-7	10μG	₹56571.45	2022-06-14	Buy

Product number	Packaging	Price	Buy
F4425	10μG	₹56571.45	Buy

FOSTRIECIN SODIUM SALT Chemical Properties,Uses,Production

Description

Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC₅₀s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC₅₀s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antibiotic.

Uses

Antineoplastic. Fostriecin is a Topo II, PP1, and PP2A inhibitor.

Biological Activity

Originally identified as an antitumor antibiotic from Streptomyces pulveraceous . Displays potent inhibition of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC 50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC 50 = 40 μ M) and protein phosphatase type 1 (PP1) (IC 50 = 131 μ M) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo .

FOSTRIECIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

FOSTRIECIN SODIUM SALT Suppliers

Global( 64)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Zhuzhou Yaozhijie Chemical Co., LTD	+8618073316972	China	244	58	Inquiry
Hubei Lange Biotechnology Co., Ltd.	+8617762501948	China	154	58	Inquiry
zhuzhou dingcheng meihei comestic co.,ltd	+8618873369619	China	260	58	Inquiry
Shanghai Getian Industrial Co., LTD	+86-15373193816 +86-15373193816	China	274	58	Inquiry
.GZ HONESTCHEM CO.,LTD	+86-15013270415	China	246	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	China	2132	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30253	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	China	9030	58	Inquiry
Jiangsu shring Biopharma Co., Ltd.	+8613372282299	China	3545	58	Inquiry
Wuhan Han Sheng New Material Technology Co.，Ltd	+8617798174412	China	2118	58	Inquiry

Supplier	Advantage
Zhuzhou Yaozhijie Chemical Co., LTD	58
Hubei Lange Biotechnology Co., Ltd.	58
zhuzhou dingcheng meihei comestic co.,ltd	58
Shanghai Getian Industrial Co., LTD	58
.GZ HONESTCHEM CO.,LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
Career Henan Chemica Co	58
Shaanxi Dideu Medichem Co. Ltd	58
Jiangsu shring Biopharma Co., Ltd.	58
Wuhan Han Sheng New Material Technology Co.，Ltd	58

87860-39-7(FOSTRIECIN SODIUM SALT)Related Search:

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Cladospirone bisepoxide Cochliodinol,fromChaetomiumglobosum. 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl- FOSTRIECIN SODIUM SALT Fostriecin

Fostriecin, Streptomyces pulveraceous Fostriecin,StreptomycesPulveraceoussubsp.Fostreus FOSTRIECIN

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11-tridecatetraenyl)-monosodiumsalt antibioticci920sodiumsalt antibioticcl1565asodiumsalt ci920sodiumsalt cl1565asodiumsalt PHOSPHOTRIENIN fostriecin sodium salt from streptomyces pulveraceus FST FOSTRIECIN FOSTRIECIN SODIUM FOSTRIECIN SODIUM SALT FOSTRIECIN, SODIUM SALT, STREPTOMYCES PULVERACEOUS CL-920 (6R)-5,6-DIHYDRO-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-TRIHYDROXY-3-METHYL-4-(PHOSPHONOOXY)-1,7,9,11-TRIDECATETRAENYL]-2H-PYRAN-2-ONE SODIUM SALT (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-onesodiumsalt (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one monosodium salt Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem FST344 Fostriecin sodium salt from Streptomyces pulveraceus >=98% (HPLC) Human FST Protein, Fc Tag FOSTRIECIN SODIUM SALT USP/EP/BP 87860-39-7 C19H27O9P C19H26O9PNa BioChemical Cell Signaling and Neuroscience Cell Biology Kinase/Phosphatase Biology Protein Phosphatase 2 (PP2) Serine/Threonine Phosphatase Inhibitors Active Pharmaceutical Ingredients FST