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ChemicalBook > Product Catalogue >API >Antibiotics >Polyenes drug >FOSTRIECIN SODIUM SALT

FOSTRIECIN SODIUM SALT

FOSTRIECIN SODIUM SALT Structure
  • ₹56571.45
  • Product name: FOSTRIECIN SODIUM SALT
  • CAS: 87860-39-7
  • MF: C19H28NaO9P
  • MW: 454.39
  • EINECS:
  • MDL Number:MFCD01939908
  • Synonyms:11-tridecatetraenyl)-monosodiumsalt ;antibioticci920sodiumsalt ;antibioticcl1565asodiumsalt ;ci920sodiumsalt ;cl1565asodiumsalt ;PHOSPHOTRIENIN;fostriecin sodium salt from streptomyces pulveraceus;FST
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Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 10μG
  • ManufacturerSigma-Aldrich(India)
  • Product numberF4425
  • Product descriptionFostriecin sodium salt from Streptomyces pulveraceus ≥98% (HPLC)
  • Packaging10μG
  • Price₹56571.45
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) F4425 Fostriecin sodium salt from Streptomyces pulveraceus ≥98% (HPLC) 10μG ₹56571.45 2022-06-14 Buy

Properties

storage temp. :-20°C
solubility :Soluble in H2O
form :Colorless solid
Water Solubility :Soluble to 100 mM in water
InChIKey :GMNLFZGMQHSFFV-DSXPUHJBNA-N
SMILES :[C@@H](OP(O)(O)=O)(C[C@@H](O)/C=C\C=C/C=C/CO)[C@@](O)(C)/C=C/[C@H]1CC=CC(=O)O1.[NaH] |&1:0,7,17,22,r|

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H402 Harmful to aquatic life Hazardous to the aquatic environment, acute hazard Category 3
Precautionary statements:
P273 Avoid release to the environment.
P501 Dispose of contents/container to..…

Description

Fostriecin is an antibiotic originally derived from Streptomyces pulveraceus. This compound has been shown to inhibit the catalytic activity of partially purified Topo II (type II topoisomerase) in a non-competitive manner. Unlike other known inhibitors of this enzyme, fosteriecin has not been observed to cause DNA strand breaks in L1210 cells, suggesting that it does not stabilize a cleavable complex. Furthermore, in the same experiment, this agent was demonstrated to cause a block in the G2 phase of the cell cycle. Fostriecin has also displayed a strong capacity to inhibit protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A).

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