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KAZUSAMYCIN A FROM STREPTOMYCES SP.

KAZUSAMYCIN A  FROM STREPTOMYCES SP. Structure
  • ₹0
  • Product name: KAZUSAMYCIN A FROM STREPTOMYCES SP.
  • CAS: 92090-94-3
  • MF: C33H48O7
  • MW: 556.73
  • EINECS:
  • MDL Number:MFCD03265635
  • Synonyms:KAZUSAMYCIN A FROM STREPTOMYCES SP.;antibiotic81-484 ;antibioticcl1957b ;kazusamycin ;kazusamycina ;19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-8-oxo-2,10,12,16,18-nonadecapentenoic acid;PD-114721;2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-8-oxo-, (2E,10E,12E,16Z,18E)-
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Properties

Boiling point :761.5±60.0 °C(Predicted)
Density :1.109±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :methanol/water: 7:3, soluble
form :aqueous methanol solution
pka :5.10±0.33(Predicted)

Safety Information

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Description

Kazusamycin A is an antibiotic from Streptomyces and a hydroxy analog of Leptomycin B that demonstrates cytotoxic activity against various human and mouse tumor lines. Additionally, at nanomolar concentrations, it inhibits nuclear export and translocation of Rev, a regulatory gene product in the HIV genome.

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