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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Antibiotics anticancer drugs >Daunorubicin hydrochloride

Daunorubicin hydrochloride

Daunorubicin hydrochloride Structure
  • ₹3972.78 - ₹28718.73
  • Product name: Daunorubicin hydrochloride
  • CAS: 23541-50-6
  • MF: C27H29NO10.ClH
  • MW: 563.98
  • EINECS:245-723-4
  • MDL Number:MFCD04974507
  • Synonyms:5,12-Naphthacenedione,8-acetyl-10-[(3-aMino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-Methoxy-,hydrochloride (1:1), (8S,10S)-;daunoblastin ;daunoblastina ;daunomycinchlorohydrate ;ndc0082-4155 ;ondena ;rp13057hydrochloride ;rubidomycinhydrochloride
Price6 Properties Safety Information Description
6 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • 10MG
  • 20MG
  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberD4532
  • Product descriptionDaunorubicin Hydrochloride
  • Packaging20MG
  • Price₹4700
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD4532
  • Product descriptionDaunorubicin Hydrochloride
  • Packaging100MG
  • Price₹10800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD8809
  • Product descriptionDaunorubicin hydrochloride meets USP testing specifications
  • Packaging1MG
  • Price₹3972.78
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number30450
  • Product descriptionDaunorubicin hydrochloride ≥90% (HPLC)
  • Packaging5MG
  • Price₹12621.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD8809
  • Product descriptionDaunorubicin hydrochloride meets USP testing specifications
  • Packaging10MG
  • Price₹17449.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number30450
  • Product descriptionDaunorubicin hydrochloride ≥90% (HPLC)
  • Packaging25MG
  • Price₹28718.73
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) D4532 Daunorubicin Hydrochloride 20MG ₹4700 2022-05-26 Buy
TCI Chemicals (India) D4532 Daunorubicin Hydrochloride 100MG ₹10800 2022-05-26 Buy
Sigma-Aldrich(India) D8809 Daunorubicin hydrochloride meets USP testing specifications 1MG ₹3972.78 2022-06-14 Buy
Sigma-Aldrich(India) 30450 Daunorubicin hydrochloride ≥90% (HPLC) 5MG ₹12621.95 2022-06-14 Buy
Sigma-Aldrich(India) D8809 Daunorubicin hydrochloride meets USP testing specifications 10MG ₹17449.9 2022-06-14 Buy
Sigma-Aldrich(India) 30450 Daunorubicin hydrochloride ≥90% (HPLC) 25MG ₹28718.73 2022-06-14 Buy

Properties

Melting point :190°C (dec)
alpha :D20 +248 ±5° (c = 0.05-0.1 in methanol)
storage temp. :Inert atmosphere,2-8°C
solubility :Freely soluble in water and in methanol, slightly soluble in alcohol, practically insoluble in acetone.
form :solid
color :red to deep red
Water Solubility :Soluble in water (50 mM)
λmax :477nm(H2O)(lit.)
Sensitive :Hygroscopic
Merck :14,2832
BRN :4229221
Stability :Stability
EPA Substance Registry System :Daunorubicin hydrochloride (23541-50-6)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Daunorubicin is an antitumor antibiotic widely used in the treatment of acute myeloid leukemias (AMLs). At 0.2-1μM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 AML cells. However, immature AML cells (CD 34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations. In mature AML cells, daunorubicin has been shown to trigger a ROS-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK cascade leading to enhanced DNA binding activity of the transcription factor AP-1.

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Suppliers and manufacturers

GLP Pharma Standards Hetero Drugs Limited Sakar Healthcare AKASH PHARMA EXPORTS SynZeal Research Pvt Ltd Pharmaffiliates Analytics and Synthetics P. Ltd Padarsh Pharmaceuticals Pvt Ltd CLEARSYNTH LABS LTD. TCI Chemicals (India) Pvt. Ltd. Oceanic Pharmachem Pvt. Ltd.