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neoantimycin

neoantimycin Structure
  • ₹0
  • Product name: neoantimycin
  • CAS: 22862-63-1
  • MF: C36H46N2O12
  • MW: 698.76
  • EINECS:
  • MDL Number:MFCD11111613
  • Synonyms:neoantimycin;N-(15-Benzyl-10-sec-butyl-14-hydroxy-3-isopropyl-7,13,13-trimethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraoxacyclopentadeca-6-yl)-3-formylamino-2-hydroxybenzamide;Benzamide, 3-(formylamino)-2-hydroxy-N-[(3S,6S,7R,10S,14R,15R)-14-hydroxy-7,13,13-trimethyl-3-(1-methylethyl)-10-[(1S)-1-methylpropyl]-2,5,9,12-tetraoxo-15-(phenylmethyl)-1,4,8,11-tetraoxacyclopentadec-6-yl]-
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :930.3±65.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form :White to off-white solid.
pka :7.24±0.50(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Neoantimycin is a macrocyclic antibiotic isolated from Streptomyces bacteria. The mechanism of action of Neoantimycin is undescribed in the literature. A closely related compound described as an oxidized-type neoantimycin, prunustatin A, is demonstrated to downregulate grp78 transcription and suppress the expression of the GRP 78 molecular chaperone. This suppression affects the role of GRP 78 in promoting protein folding at the endoplasmic reticulum (ER), and suppresses the pro-resistance enhancement of ER stress response by chemotherapy-resistant tumors. The close structural kinship between prunustatin A and Neoantimycin suggests a similar mechanism of action for Neoantimycin toxicity.

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Suppliers and manufacturers

CLEARSYNTH LABS LTD.
BOC Sciences
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Aladdin Scientific Shanghai Aladdin Bio-Chem Technology Co.,LTD Beijing Lebo Biotechnology Co., Ltd. Zhejiang Huida Biotech Co., LTD Zhejiang Huida Biotech Co., LTD Cayman Chemical Company Shanghai EFE Biological Technology Co., Ltd.