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PD 124895

PD 124895 Structure
  • ₹0
  • Product name: PD 124895
  • CAS: 107140-30-7
  • MF: C32H46O7
  • MW: 542.7
  • EINECS:
  • MDL Number:MFCD01716600
  • Synonyms:PD 124895;4,8,10,14,18,20,22-Heptamethyl-16-hydroxymethyl-5,19-dihydroxy-17-oxo-2,6,8,12,14,22-tetracosahexenedioic acid δ-lactone;Antibiotic CL-1957E;Antibiotic PD-124895;CL-1957E;Kazusamycin B;HydroxyleptoMycin A, CL 1957E, PD 124895, PD 124,895;6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
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Properties

storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :Colorless film.

Safety Information

Symbol(GHS):
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Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
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Description

Kazusamycin B is a minor component of the leptomycin complex produced by some Streptomyces sp.. It is an hydroxylated analogue of leptomycin A, a nuclear export inhibitor. Kazusamycin B displays potent antitumour activity against L1210 and human colon adenocarcinoma, and in vivo activity against P388 lymphocytic leukemia in mice. Kazusamycin B also possesses strong antibacterial and antifungal activity.

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