Dexchlorpheniramine Maleate
- CAS No.
- 2438-32-6
- Chemical Name:
- Dexchlorpheniramine Maleate
- Synonyms
- Polamin;Phenamin;Sensidyn;polaramin;Polaramine;d-Form maleate;poraminemaleate;polaraminemaleate;D-CHLORPHENIRAMINE MALEATE;Chlorpheniramine d-maleate
- CBNumber:
- CB8392741
- Molecular Formula:
- C20H23ClN2O4
- Molecular Weight:
- 390.86
- MOL File:
- 2438-32-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:32
| Melting point | 112-115 °C(lit.) |
|---|---|
| alpha | D25 +44.3° (c = 1 in dimethylformamide) |
| storage temp. | 2-8°C |
| solubility | Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride. |
| form | Solid |
| color | White to off-white |
| PH | pH(10g/l, 25℃) : 4.0～5.0 |
| Merck | 13,2198 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P330+P331+P310 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US6504000 | |||||||||
| HS Code | 2933399090 | |||||||||
| NFPA 704 |
|
Dexchlorpheniramine Maleate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C4915 | S-(+)-Chlorpheniramine maleate salt | 2438-32-6 | 1G | ₹9082.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2803 | Dexchlorpheniramine Maleate | 2438-32-6 | 500MG | ₹15360.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C4915 | S-(+)-Chlorpheniramine maleate salt | 2438-32-6 | 5G | ₹35538.48 | 2022-06-14 | Buy |
Dexchlorpheniramine Maleate Chemical Properties,Uses,Production
Description
Dexchlorpheniramine Maleate is the maleate salt form of dexchlorpheniramine, an alkylamine, and first-generation histamine antagonist with anti-allergic activity. Dexchlorpheniramine maleate competitively blocks H1 receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.
Chemical Properties
Dexchlorpheniramine maleate is a white, odourless, crystalline powder which in aqueous solution has a pH of between 4 and 5. It is freely soluble in water, soluble in alcohol and in chloroform, but only slightly soluble in benzene or ether.
Uses
Dexchlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. Polaramine (dexchlorpheniramine maleate) is the dextro-isomer of chlorpheniramine maleate and the S-enantiomer of Chlorpheniramine. It is an antihistamine with anticholinergic properties. S-(+)-Chlorpheniramine maleate salt has been used to study the anticholinergic effect of Achillea millefolium and Portulaca olerace on muscarinic receptors of guinea pig tracheal smooth muscle.
General Description
Dexchlorpheniramine(Polaramine) is the dextrorotatory enantiomer of chlorpheniramine.In vitro and in vivo studies of the enantiomers ofchlorpheniramine showed that the antihistaminic activity existspredominantly in the dextro isomer. As mentioned previously,the dextro isomer has the (S) configuration, which issuperimposable on the (S) configuration of the more activelevorotatory enantiomer of carbinoxamine.
Mode of action
Dexchlorpheniramine, the d-isomer of the racemic compound chlorpheniramine, is two times more active than chlorpheniramine. Dexchlorpheniramine does not prevent the release of histamine, but rather, competes with free histamine for binding at the H1-receptor sites, and competitively antagonizes the effects of histamine on H1- receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Blockade of H1-receptors also suppresses the formation of oedema, flare, and pruritus that result from histaminic activity. Since dexchlorpheniramine binds to central and peripheral H1-receptors, sedative effects are likely to occur. H1- antagonists are structurally similar to anticholinergic agents and therefore possess the potential to exhibit anticholinergic properties of varying degrees. They also have antipruritic effects. Dexchlorpheniramine has high antihistaminic activity, moderate anticholinergic effects and minimal sedative effects. The medicine does not possess antiemetic properties.
References
[1] P. E. CHAVES. Assessment of cytotoxicity, genotoxicity, and mutagenicity of the dexchlorpheniramine reference standard and pharmaceutical formula in human peripheral blood mononuclear cells[J]. Brazilian Journal of Pharmaceutical Sciences, 2022, 18 1. DOI:10.1590/s2175-97902022e20096.
[2] GUSTAVO FACCHINI MSC. Ultraviolet A photosensitivity profile of dexchlorpheniramine maleate and promethazine-based creams: Anti-inflammatory, antihistaminic, and skin barrier protection properties[J]. Journal of Cosmetic Dermatology, 2017, 16 4: e59-e67. DOI:10.1111/jocd.12349.
[3] MASAAKI TAGAWA. Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine.[J]. British journal of clinical pharmacology, 2001, 52 5 1: 501-509. DOI:10.1046/J.1365-2125.2001.01471.X.
[4] DONG LIANG. Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning[J]. Acta Pharmaceutica Sinica B, 2022, 12 5: Pages 2429-2442. DOI:10.1016/j.apsb.2021.12.005.
Dexchlorpheniramine Maleate Preparation Products And Raw materials
Dexchlorpheniramine Maleate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Halcyon Labs Pvt. Ltd | +919833750169 | Mumbai, India | 17 | 58 | Inquiry |
| Afton Pharma | +91-9712000202 +91-9712000202 | Gujarat, India | 63 | 58 | Inquiry |
| Supriya Lifescience Ltd | +91-9820804279 +91-9821266261 | Maharashtra, India | 27 | 58 | Inquiry |
| Venkatasai Life Sciences | +91-9908134868 +91-8008303069 | Hyderabad, India | 186 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Keshava Organics Pvt Ltd | 91-22-29271436 | Maharashtra, India | 7 | 58 | Inquiry |
| Darshan Pharma Chem | +91-8460053621 +91-9924796811 | Gujarat, India | 42 | 58 | Inquiry |
| Amar Healthcare | +91-9824100314 +91-9512041602 | Gujarat, India | 34 | 58 | Inquiry |
| Nivedita Chemicals Pvt Ltd (Anek Prayog Pvt Ltd) | +91-2228329337 +91-2228327321 | Maharashtra, India | 17 | 58 | Inquiry |
| Mahrshee Laboratories Pvt Ltd | +91-9824100314 +91-9227402952 | Gujarat, India | 63 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Halcyon Labs Pvt. Ltd | 58 |
| Afton Pharma | 58 |
| Supriya Lifescience Ltd | 58 |
| Venkatasai Life Sciences | 58 |
| Ralington Pharma | 58 |
| Keshava Organics Pvt Ltd | 58 |
| Darshan Pharma Chem | 58 |
| Amar Healthcare | 58 |
| Nivedita Chemicals Pvt Ltd (Anek Prayog Pvt Ltd) | 58 |
| Mahrshee Laboratories Pvt Ltd | 58 |