ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Phosphine ligand >Propylphosphonic anhydride
Propylphosphonic anhydride
- CAS No.
- 68957-94-8
- Chemical Name:
- Propylphosphonic anhydride
- Synonyms
- T3P;1-PROPANEPHOSPHONIC ANHYDRIDE;PPACA;1-PROPANEPHOSPHONIC ACID CYCLIC ANHYDRIDE;PROPANE PHOSPHONIC ACID ANHYDRIDE;1-PROPYLPHOSPHONIC ACID CYCLIC ANHYDRIDE;2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide;PPAA;Propylphosphonic acid anhydride;T3P/Propanephosphonic acid cyclic anhydride
- CBNumber:
- CB8462554
- Molecular Formula:
- C9H21O6P3
- Molecular Weight:
- 318.18
- MOL File:
- 68957-94-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/15 10:43:35
| Boiling point | 65 °C |
|---|---|
| Density | 1.069 g/mL at 25 °C |
| vapor pressure | 0Pa at 25℃ |
| refractive index |
n |
| Flash point | 25 °F |
| storage temp. | Flammables area |
| solubility | Miscible with dioxane, terahydrofuran, dimethyl formamide, polar and aprotic organic solvents. |
| form | Solution |
| color | Clear yellow to brownish |
| Water Solubility | 9.6g/L at 25℃ |
| Sensitive | Moisture Sensitive |
| BRN | 5079255 |
| Exposure limits |
ACGIH: TWA 20 ppm (Skin) OSHA: TWA 40 ppm(70 mg/m3) NIOSH: IDLH 137 ppm(25 mg/m3); TWA 20 ppm(34 mg/m3) |
| Stability | Moisture Sensitive |
| LogP | 0 at 25℃ |
| CAS DataBase Reference | 68957-94-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H290-H314-H336 | |||||||||
| Precautionary statements | P210-P233-P234-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | T,C,F | |||||||||
| Risk Statements | 61-20/21-34-67-66-11 | |||||||||
| Safety Statements | 53-26-36/37/39-45-33-16 | |||||||||
| RIDADR | UN 2924 3/PG 3 | |||||||||
| WGK Germany | 1 | |||||||||
| F | 21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29319019 | |||||||||
| NFPA 704 |
|
Propylphosphonic anhydride price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.43944 | Propanephosphonic acid anhydride (50% solution in Dimethyl formamide) for synthesis T3P | 68957-94-8 | 25ML | ₹4850 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 81801 | Propylphosphonic anhydride solution technical, ~50% in DMF | 68957-94-8 | 25ML | ₹9669.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.43944 | Propanephosphonic acid anhydride (50% solution in Dimethyl formamide) for synthesis T3P | 68957-94-8 | 50ML | ₹8449.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 81801 | Propylphosphonic anhydride solution technical, ~50% in DMF | 68957-94-8 | 100ML | ₹36402.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.43944 | Propanephosphonic acid anhydride (50% solution in Dimethyl formamide) for synthesis T3P | 68957-94-8 | 100ML | ₹13200 | 2022-06-14 | Buy |
Propylphosphonic anhydride Chemical Properties,Uses,Production
Chemical Properties
Clear light yellow solution
Uses
Propylphosphonic anhydride may be used in the following studies:
- As coupling agent for the synthesis of bispyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs.
- Microwave-assissted Fischer indolization of arylhydrazines.
- As acid activating agent for the direct synthesis of acid azides from carboxylic acids.
- One-pot synthesis of coumarins.
- Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones.
- One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.
- Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.
General Description
Propylphosphonic anhydride (T3P) is a reactive n-propyl phosphonic acid cyclic anhydride. It is a mild and low toxic coupling agent used in peptide synthesis. T3P also acts as a promoter and water scavenger in the Friedl?nder annulation reaction. It participates in the conversion of carboxylic acids and amides into nitriles, formation of Weinreb amides, ester synthesis, dehydrations, oxidation of alcohols, isonitrile synthesis, synthesis of alkenes from alcohols and C-C coupling reactions. T3P delivers outstanding advantages over traditional reagents, such as broad functional group tolerance, low epimerization, and water-soluble by-products and hence gives high purity and yield of the product.
Propylphosphonic anhydride Preparation Products And Raw materials
Raw materials
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