Triethyl phosphite
- CAS No.
- 122-52-1
- Chemical Name:
- Triethyl phosphite
- Synonyms
- P(OEt)3;triethyl;TRIETHYLPHOSPHILE;Triethylphosphit;Triethyl Phosphite(TEP);PHOSPHOROUS ACID TRIETHYL ESTER;TRIETHYLPHOSPHITE FOR SYNTHESIS;P(EtO)3;(C2H5O)3P;AURORA KA-1231
- CBNumber:
- CB9702666
- Molecular Formula:
- C6H15O3P
- Molecular Weight:
- 166.16
- MOL File:
- 122-52-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/12/24 16:54:11
| Melting point | -112°C |
|---|---|
| Boiling point | 65 °C |
| Density | 0.969 g/mL at 25 °C(lit.) |
| vapor pressure | <6 hPa (20 °C) |
| refractive index |
n |
| Flash point | 130 °F |
| storage temp. | Flammables area |
| solubility | Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly) |
| form | liquid |
| color | colorless |
| Specific Gravity | 0.969 |
| Odor | characteristic, obnoxious, phosphiteodor |
| explosive limit | 3.75-42.5%(V) |
| Water Solubility | slightly soluble |
| Sensitive | Air & Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 956578 |
| Dielectric constant | 10.9（65℃） |
| Stability | Air Sensitive, Moisture Sensitive |
| CAS DataBase Reference | 122-52-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Phosphorous acid, triethyl ester(122-52-1) |
| EPA Substance Registry System | Triethyl phosphite (122-52-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H302-H317-H412 | |||||||||
| Precautionary statements | P210-P233-P273-P280-P301+P312-P303+P361+P353 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 10-22-36/37/38-20/22 | |||||||||
| Safety Statements | 16-26-36 | |||||||||
| RIDADR | UN 2323 3/PG 3 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | TH1130000 | |||||||||
| F | 10-23 | |||||||||
| Autoignition Temperature | 250 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2920 24 00 | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| Toxicity | LD50 orl-rat: 1840 mg/kg JACTDZ 1,218,92 | |||||||||
| NFPA 704 |
|
Triethyl phosphite price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T61204 | Triethyl phosphite 98% | 122-52-1 | 5ML | ₹1948.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T61204 | Triethyl phosphite 98% | 122-52-1 | 100ML | ₹1948.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T61204 | Triethyl phosphite 98% | 122-52-1 | 500ML | ₹6992.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T61204 | Triethyl phosphite 98% | 122-52-1 | 1L | ₹7166.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.00549 | Triethylphosphite for synthesis | 122-52-1 | 100ML | ₹2430 | 2022-06-14 | Buy |
Triethyl phosphite Chemical Properties,Uses,Production
Chemical Properties
Triethyl phosphite is a clear colorless liquid with a strong foul odor. Insoluble in water; soluble in alcohol and ether. Combustible.Vapors heavier than air.
Uses
Triethyl phosphite is an organophosphorus compound. It is used as a reducing agent; can react with electrophiles to form phosphonates or phosphates; forms a stable complex with copper(I) iodide.
Triethyl phosphite is a very good nucleophile. The carbon adjacent to the bromine is the most electrophilic position, and phosphorus is the only nucleophile. Triethyl phosphite displaces the bromine in an SN2-like process, and back attack by the bromide which is released generates a phosphonate product, in which the α-protons are strongly acidic.
Preparation
Triethyl phosphite is produced in a closed system by reaction of phosphorous trichlorid and ethanol in the presence of an inorganic or organic base. The product is purified by distillation (Bayer AG, 2002a).
Triethyl phosphite is exclusively used as an intermediate for the manufacturing of different products: flame retardants (about 60 %), optical brighteners (about 15 %), pesticides (about 15 %), antioxidants (about 5 %), and pharmaceuticals (about 5 %).
Reactions
This reaction is currently used for the preparation of synthetically useful phosphonate reagents employed in modified retinal studies. Thus, diethyl 3-alkoxycarbonyl-2-propenylphosphonates are prepared in 72-91% yields by the reaction of methyl or ethyl 4-bromocrotonates with triethyl phosphite at 150-160°C. Similarly, diethyl 3-(ethoxycarbonyl)-2 methyl-2-propenylphosphonate is prepared in 81% yield from triethyl phosphite and ethyl 3-methyl-4-chlorocrotonate by heating at 180- 200°C.The diethyl (E)- and (Z)-3-ethoxycarbonyl-3 fluoro-2 -methyl-2-propenylphosphonates are respectively obtained from triethyl phosphite and (E)- or (Z)-4-bromo-2-fuoro-3-methyl-2-butenoates at 140°C.
Reactivity Profile
Triethyl phosphite is colorless, moderately toxic liquid, combustible. Flammable when exposed to heat or flame. When heated to decomposition Triethyl phosphite emits toxic fumes of oxides of phosphorus [Lewis, 3rd ed., 1993, p. 1271].
Health Hazard
Exposure to high concentrations may cause headache, nausea, and dizziness due to reduced chlolinesterase activity.
Fire Hazard
Special Hazards of Combustion Products: May form hazardous decomposition products.
Safety Profile
Moderately toxic by ingestion. A skin and eye irritant. Flammable liquid when exposed to heat, sparks, or flame. When heated to decomposition it emits toxic fumes of POx.
Triethyl phosphite Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| V B Organics | +91-9912996647 +91-9912996647 | Telangana, India | 13 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| United Phosphorus Limited | +91-2271528737 +91-9004390689 | Mumbai, India | 32 | 58 | Inquiry |
| VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2096 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| V B Organics | 58 |
| JSK Chemicals | 58 |
| United Phosphorus Limited | 58 |
| VASIN BIO LIFE SCIENCES PVT LTD | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Central Drug House(P) Ltd. | 58 |
| Triveni chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
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