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DMT-2′Fluoro-dU Phosphoramidite

CAS No.: 146954-75-8

Chemical Name:: DMT-2′Fluoro-dU Phosphoramidite

Synonyms: 2‘-F-U amidite;2'-Fluoro-dU CEP;2’-F-dU Amidite;2’-F-rUPhosphoramidite;2'-F-U Phosphoramidite;2'-F-dU Phosphoramidite;5'-O-DMT-2'-fluoro-dU-CE;5'-O-DMT-2'-F-dU-3'-CEDPA;2'-Fluoro Uridine Amidite;2'-Fluoro Uridine Amidite

CBNumber:: CB8500324

Molecular Formula:: C39H46FN4O8P

Molecular Weight:: 748.78

MOL File:: 146954-75-8.mol

MSDS File:: SDS

Modify Date:: 2024/7/24 9:14:08

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DMT-2′Fluoro-dU Phosphoramidite Properties

storage temp.	Sealed in dry,Store in freezer, under -20°C
form	powder
pka	9.39±0.10(Predicted)
color	white to off-white
InChIKey	HQHQPAYRJJMYQX-YOKGOYKLNA-N
SMILES	N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2C=CC(=CC=2)OC)C2=CC=C(C=C2)OC)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]1F \|&1:8,10,36,51,r\|

SAFETY

Risk and Safety Statements

WGK Germany	3

DMT-2′Fluoro-dU Phosphoramidite price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	U211280	DMT-2′Fluoro-dU Phosphoramidite configured for PerkinElmer, configured for Polygen	146954-75-8	0.25G	₹6083.65	2022-06-14	Buy
Sigma-Aldrich(India)	U211280	DMT-2′Fluoro-dU Phosphoramidite configured for PerkinElmer, configured for Polygen	146954-75-8	1G	₹17006.08	2022-06-14	Buy
Sigma-Aldrich(India)	U211280	DMT-2′Fluoro-dU Phosphoramidite configured for PerkinElmer, configured for Polygen	146954-75-8	2G	₹35603.43	2022-06-14	Buy
Sigma-Aldrich(India)	U211250	DMT-2′Fluoro-dU Phosphoramidite configured for (?KTA? and OligoPilot?)	146954-75-8	1G	₹17006.08	2022-06-14	Buy
Sigma-Aldrich(India)	U211250	DMT-2′Fluoro-dU Phosphoramidite configured for (?KTA? and OligoPilot?)	146954-75-8	5G	₹94264.1	2022-06-14	Buy

Product number	Packaging	Price	Buy
U211280	0.25G	₹6083.65	Buy
U211280	1G	₹17006.08	Buy
U211280	2G	₹35603.43	Buy
U211250	1G	₹17006.08	Buy
U211250	5G	₹94264.1	Buy

DMT-2′Fluoro-dU Phosphoramidite Chemical Properties,Uses,Production

Uses

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite (DMT-2′Fluoro-dU Phosphoramidite) is a uridine phosphoramidite consisting of a fluorine in the 2' position, and the compound is used in the synthesis of DNA.

Definition

DMT-2′Fluoro-dU Phosphoramidite is also known as 2'-F-U CE-Phosphoramidite. 2'-F-RNA oligonucleotides adopt an A-form helix on hybridisation to a target. Whereas a hydroxyl group of RNA is a hydrogen bond donor, fluorine appears to be a weak acceptor. These features of 2'-F-RNA oligonucleotides lead to certain interesting properties. For example, it was demonstrated that oligonucleotides hybridise to a RNA oligonucleotide in the following order of increasing stability: DNA < RNA < 2'-OMe-RNA < 2'-F-RNA

Synthesis

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine (3.00 g, 5.47 mmol) was dissolved in anhydrous dichloromethane (50 ml) under an argon atmosphere, N,N-diisopropylethylamine (0.55 ml,3.18 mmol), 1H-tetrazole (0.45 g, 6.45 mmol) and 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite (1.92 g, 6.36mmol) were added. And the mixture was stirred at room temperature overnight. The completion of the reaction was confirmed, 5 percent aqueous sodium hydrogen carbonate solution (20 ml) was added to the reaction mixture to allow layer separation, and the organic layer was washed with saturated brine (20 ml). The organic layer was dried over sodium sulfate, the filtrate was concentrated and the obtained crude product was purified by silica gel chromatography (hexane:ethyl acetate=75:25 - 30/70(v/v), containing 3percent triethylamine). The object fractions were collected and concentratedto give DMT-2′Fluoro-dU Phosphoramidite (2.76 g, 67.3 percent).

DMT-2′Fluoro-dU Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

DMT-2′Fluoro-dU Phosphoramidite Suppliers

Global( 168)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.B.ENTERPRISES	+91-9223381464 +91-9223381464	Maharashtra, India	78	58	Inquiry
Innovassynth Technologies (I) Ltd.	+91-2192260100 +91-7208872197	Maharashtra, India	118	58	Inquiry
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A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
A. B. Enterprises	+91-8048077585	Mumbai, India	1396	58	Inquiry
Allbiosyn Biotechnology Co.,Ltd.	+8618666985712	China	286	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	18656	58	Inquiry
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Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10311	58	Inquiry
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	China	321	58	Inquiry

Supplier	Advantage
A.B.ENTERPRISES	58
Innovassynth Technologies (I) Ltd.	58
Gagri Global IT Services Pvt. Ltd.	58
A.J Chemicals	58
A. B. Enterprises	58
Allbiosyn Biotechnology Co.,Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Yunbio Tech Co.,Ltd.	58

146954-75-8(DMT-2′Fluoro-dU Phosphoramidite)Related Search:

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Uridine DMT-2′Fluoro-dU Phosphoramidite

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2'-Fluoro-5'-O-DMT-2'-deoxyuridine-3'-CE-Phosphoramidite 5'-DMT-2'-F-rU Phosphoramidite DMT-2'-F-DU AMIDITE 0.25G, AB, SINGLE DMT-2'-F-dU Amidite 0.25g, 89, Single 2’-F-rUPhosphoramidite 5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 5'-O-DMT-2'-F-dU-3'-CEDPA 2'-F-dU Phosphoramidite 2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine-3'-CED PhosphoraMidite DMT-2′Fluoro-dU Phosphoramidite 3-({[(2-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-5-(2,4-DIOXO-3H-PYRIMIDIN-1-YL)-4-FLUOROOXOLAN 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite 2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine Phosphoramidite 5'-O-DMT-2'-Fluoro-2'-deoxyuridine 3'-CE phosphoramidite 2'-Fluoro-dU CEP Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] 5'-Dimethoxytrityl-deoxyUridine, 2'-fluoro-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite 2'-Fluoro-N2-Isobutyryl-5'-O-DMT-2'-Deoxyguanosine-3'-CE-Phosphoramidite 5'-DMTr-2'-F-3'-O-CEP-URIDINE 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit 2‘-F-U amidite DMT-2'-F-U Phosphoramidite DMT-2’-F-dU-CE Phosphoramidite 5'-O-DMT-2'-fluoro-dU-CE Inhibitor,Nucleoside Antimetabolite/Analog,DMT2′FluorodU Phosphoramidite,inhibit,DMT 2′Fluoro dU Phosphoramidite 5'-O-DMT-2'-F-2'-Deoxy Uridine -3’-Cyanoethyl Phosphoramidite 2'-Fluoro Uridine Amidite 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-tetrahydrofuran-3-yl]oxy-(diisopropylamino)phosphanyl]oxypropanenitrile DMTr-2'-F-dU-3'-CE-Phosphoramidite 2’-F-dU Amidite 5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-CE-Phosphoramidite 5'-ODMT-2'-Fluoro uridine-3'-OCEPA 2'-F-U Phosphoramidite DMT-2'-F-dU-CE Phosphoramidite 5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit 2'-Fluoro-2'-deoxy Uridine CED Phosphoramidite 2'-F-5'-O-DMT-2'-dU-3'-CE-Phosphoramidite DMTr-2'-F-dU-3'-CE-Phosphoramidite 5'-O-DMT-2'-fluoro-2'-Deoxyuridine 3'-CE phosphoramidite 5'-O-DMT-2'-F-2'-Deoxy Uridine -3’-Cyanoethyl Phosphoramidite 2'-Fluoro Uridine Amidite DMT-2'FLUORO-DU PHOSPHORAMIDITE Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite 146954-75-8 Amidite