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ChemicalBook > Product Catalog >Biochemical Engineering >Nucleoside drugs >Deoxynucleotides and their analogs >2'-Deoxy-2'-fluorocytidine

2'-Deoxy-2'-fluorocytidine

2'-Deoxy-2'-fluorocytidine Structure
CAS No.
10212-20-1
Chemical Name:
2'-Deoxy-2'-fluorocytidine
Synonyms
2'-FC;2'-FdC;RO-8013;2'-F-dC;2'-FANA-C;NSC 529432;2’-F-2’-dC;2'-Fluoro-d-Cytidine;2'-F-2'-deoxycytidine;2'-Deoxy-2"-fuorocytidine
CBNumber:
CB8670324
Molecular Formula:
C9H12FN3O4
Molecular Weight:
245.21
MOL File:
10212-20-1.mol
Modify Date:
2024/11/11 16:49:21
Request For Quotation

2'-Deoxy-2'-fluorocytidine Properties

Melting point 167 °C
Boiling point 500.1±60.0 °C(Predicted)
Density 1.82±0.1 g/cm3(Predicted)
refractive index 80 ° (C=1, MeOH)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility Soluble in DMSO, Methanol.
pka 12.84±0.70(Predicted)
form Powder
color White to Off-white
Water Solubility Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)
InChI InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1
InChIKey NVZFZMCNALTPBY-XVFCMESISA-N
SMILES OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O
CAS DataBase Reference 10212-20-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
HS Code  29389090

2'-Deoxy-2'-fluorocytidine price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) D3614 2'-Deoxy-2'-fluorocytidine 10212-20-1 1G ₹4300 2022-05-26 Buy
Product number Packaging Price Buy
D3614 1G ₹4300 Buy

2'-Deoxy-2'-fluorocytidine Chemical Properties,Uses,Production

Description

2'-Deoxy-2'-fluorocytidine is a nucleoside analog. It has antiviral effects and can synergize with T705 to effectively inhibit Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2'-Deoxy-2'-fluorocytidine can also inhibit dihydrofolate reductase, thereby preventing the production of tetrahydrofolate, which is required for the synthesis of purines and pyrimidines. It has a certain inhibitory effect on poliovirus, herpes simplex virus, vesicular stomatitis virus and influenza A virus.

Chemical Properties

White Solid

Uses

2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s pread.

in vitro

2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.

References

[1] Stephen R. Welch. “Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus.” Antiviral research 147 (2017): Pages 91-99.

2'-Deoxy-2'-fluorocytidine Preparation Products And Raw materials

Raw materials

Preparation Products

2'-Deoxy-2'-fluorocytidine Suppliers

Global( 331)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
Reax Chemicals 08048372701Ext 416 Hyderabad, India 4217 58 Inquiry
Oceanic Pharmachem Pvt. Ltd. 91-22-42128600 Maharashtra, India 2005 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6754 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6768 58 Inquiry
ChemExpress +86-021-58950125 +86-021-58950125; China 782 58 Inquiry
INNOBIO PHARM CO.,LTD +8615600141006 China 271 58 Inquiry
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 China 29730 60 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Reax Chemicals 58
Oceanic Pharmachem Pvt. Ltd. 58
Pharma Affiliates 58
TCI Chemicals (India) Pvt. Ltd. 58
ChemExpress 58
INNOBIO PHARM CO.,LTD 58
Capot Chemical Co.,Ltd. 60

2'-Deoxy-2'-fluorocytidine Spectrum

4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one(10212-20-1)1HNMR4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one(10212-20-1)IR14-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one(10212-20-1)IR2

10212-20-1(2'-Deoxy-2'-fluorocytidine)Related Search:

Cytidine 4-amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine 5'-Deoxy-5-fluorocytidine Dmt-2'-f-dc(ac) amidite
2',2'-Difluoro-2'-deoxycytidine-3',5'-dibenzoate Gemcitabine hydrochloride 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 2''-DEOXY-2''-FLUORO-5-IODOCYTIDINE 2'-FLUORO-5'-O-DIMETHOXYTRITYL-N4-ACETYL-D-CYTIDINE
2'-DEOXY-3',5'-DI-O-BENZOYL-2',2'-DIFLUOROCYTIDINE-13C,15N2 DTBS-GEMCITABINE gemcitabine 2'-DEOXY-2'-FLUOROCYTIDINE, [3H]- 2'-FLUORO-2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE LITHIUM SALT
GEMCITABINE, [5-3H]- N4-Benzyl-2'-deoxy-2'-fluoro-5'-O-tritylcytidine-3'-O-cyanoethyldiisopropropylphosphoramidite
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4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 4-AMINO-1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-PYRIMIDIN-2-ONE 2'-FC 2'-FdC 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)cytosine 1-(2-Fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine RO-8013 2'-DEOXY-2'-FLUOROCYTIDINE(2'-FLUORO-2'- DEOXYCYTIDINE, 2'-FC) 2'-Deoxy-2'-fluoro-D-cytidine 2''-DEOXY-2''-FLUOROCYTIDINE,99+% 2'-Deoxy-2'-fluorocytidine Hydrate 2'-Deoxy-2'-fluorocytidine ,98% 2'-Fluoro-2'-deoxy-β-D-ribofuranosylcytosine FN-009 2'-Fluoro-2'-deoxy-cytidine Cytidine, 2'-deoxy-2'-fluoro- 2'-FANA-C NSC 529432 2'-Deoxy-2'-fluorocytidine  2'-Deoxy-2'-fluorocytidine≥ 99% (HPLC) Fludarabine Phosphate Impurity 18 2'-Fluoro-2'-deoxycytidine, >98.0%(T) 2'-Deoxy-2'-fluorocytidineHydrate> 2’-F-2’-dC 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one USP/EP/BP 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl... Crimean-Congo hemorrhagic fever,2' Deoxy 2' fluorocytidine,Inhibitor,nucleoside analog,inhibit,Influenza Virus,2'Deoxy2'fluorocytidine,Antiviral,CCHFV 2'-Fluoro-2'-Deoxycytidine (FdC) 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 2'-Fluoro-2'-Deoxycytidine 2'-Deoxy-2"-fuorocytidine 2'-F-2'-deoxycytidine 2'-Deoxy-2'-fluorocytidine 2'-F-dC 2'-Fluoro-d-Cytidine 2''-Deoxy-2''-fluorocytidine 10212-20-1 110212-20-1 C9H12FN3O4xH2O C9H12N3O4F C9H12FN3O4 Biochemistry Nucleosides and their analogs Nucleosides, Nucleotides & Related Reagents 10212-20-1 Nucleosides Modified（deoxy）nucleoside Nucleosides-2'-F Nucleosides