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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Quinoline compounds >4-chloro-6,7-dimethoxyquinoline

4-chloro-6,7-dimethoxyquinoline

4-chloro-6,7-dimethoxyquinoline Structure
CAS No.
35654-56-9
Chemical Name:
4-chloro-6,7-dimethoxyquinoline
Synonyms
4-Chloro-6,7-dimethoxyquioline;4-CHLORO-6;7-DIMETHOXYQUINOLINE;oro-6,7-dimethoxyquinoL;Cabozantinib Impurity 71;Cabozantinib Chloro Analog;4-CHLORO-6,7-DIMETHOXYQUINOLINE;6,7-DIMETHOXY-4-CHLOROQUINOLINE;4-Chloro-6,7-dimethoxy-quinolin;Quinoline, 4-chloro-6,7-dimethoxy-
CBNumber:
CB8725015
Molecular Formula:
C11H10ClNO2
Molecular Weight:
223.66
MOL File:
35654-56-9.mol
MSDS File:
SDS
Modify Date:
2023/12/26 17:07:23
Request For Quotation

4-chloro-6,7-dimethoxyquinoline Properties

Melting point 132.0 to 136.0 °C
Boiling point 325.2±37.0 °C(Predicted)
Density 1.265±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 3.95±0.30(Predicted)
color Pale Brown to Light Brown
InChI InChI=1S/C11H10ClNO2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3
InChIKey WRVHQEYBCDPZEU-UHFFFAOYSA-N
SMILES N1C2C(=CC(OC)=C(OC)C=2)C(Cl)=CC=1
CAS DataBase Reference 35654-56-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H315-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  T
Risk Statements  25
Safety Statements  45-24/25
RIDADR  UN2811
HazardClass  IRRITANT
HS Code  29334900
NFPA 704
0
1 0

4-chloro-6,7-dimethoxyquinoline price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) CDS007782 4-chloro-6,7-dimethoxyquinoline AldrichCPR 35654-56-9 250MG ₹9017.23 2022-06-14 Buy
TCI Chemicals (India) C2938 4-Chloro-6,7-dimethoxyquinoline min. 98.0 % 35654-56-9 5G ₹10000 2022-05-26 Buy
TCI Chemicals (India) C2938 4-Chloro-6,7-dimethoxyquinoline min. 98.0 % 35654-56-9 25G ₹28200 2022-05-26 Buy
Product number Packaging Price Buy
CDS007782 250MG ₹9017.23 Buy
C2938 5G ₹10000 Buy
C2938 25G ₹28200 Buy

4-chloro-6,7-dimethoxyquinoline Chemical Properties,Uses,Production

Chemical Properties

Light brown powder

Uses

4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.

Application

4-chloro-6,7-dimethoxy-quinoline can be rich for Buddhist nun with for Wo Zhani medicine as preparing antitumor drug card The key intermediate of thing molecule synthesis.

Synthesis

With 3,4-dimethoxyaniline is raw material, obtains aniline compound through nitrification, iron powder reducing, then with Ethyl chloroformate, in Feldalat NM condition cyclization, prepares 4-hydroxyquinoline compounds, after through three Chlorethoxyfos chloro obtains 4-chloro-6,7-dimethoxy-quinoline.
4-chloro-6,7-dimethoxyquinoline synthesis

4-chloro-6,7-dimethoxyquinoline Preparation Products And Raw materials

Raw materials

Butane, 2,2'-oxybis[2-methyl- diethyl {[(3,4-dimethoxyphenyl)amino]methylidene}propanedioate 4-Hydroxy-6,7-dimethoxyqunioline 1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE
2-[2-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-6-methylpyran-4-ylidene]propanedinitrile 3,4-Dimethoxyacetophenone 4-Aminoveratrole Acetovanillone tert-Butyl methyl ether
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Preparation Products

4-chloro-6,7-dimethoxyquinoline Suppliers

Global( 385)Suppliers
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GLR Innovations +91 9891111994 New Delhi, India 4542 58 Inquiry
Hyderabad +91-9676447615 +91-9676447615 Telangana, India 192 58 Inquiry
A.R. LIFE SCIENCES PVT. LTD. +91-914040267679 +91-8519993257 Hyderabad, India 100 58 Inquiry
SVH BIOSCIENCES +91-6303499280 +91-6303499280 Hyderabad, India 478 58 Inquiry
VGS SYNTHESIS PRIVATE LIMITED +91-9866975588 +91-9866975588 Hyderabad, India 1818 58 Inquiry
Sintilla Medcoms Pvt Ltd +91-4027808001 +91-8886733867 Telangana, India 307 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Quiver Technologies 08048371749Ext 307 Hyderabad, India 169 58 Inquiry
Supplier Advantage
GLR Innovations 58
Hyderabad 58
A.R. LIFE SCIENCES PVT. LTD. 58
SVH BIOSCIENCES 58
VGS SYNTHESIS PRIVATE LIMITED 58
Sintilla Medcoms Pvt Ltd 58
Pharma Affiliates 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Quiver Technologies 58

4-chloro-6,7-dimethoxyquinoline Spectrum

4-CHLORO-6,7-DIMETHOXYQUINOLINE(35654-56-9)1HNMR

35654-56-9(4-chloro-6,7-dimethoxyquinoline)Related Search:

Cyclopropanecarboxylic acid, 1-[[(2-fluorophenyl)amino]carbonyl]- Cabozantinib impurity 1DYH 1,1-Cyclopropanedicarboxamide, N,N'-bis[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]- Cabozantinib Malate Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]-
Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)- 1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl- Cyclopropanecarboxylic acid, 1-[[[4-[[7-methoxy-6-(sulfooxy)-4-quinolinyl]oxy]phenyl]amino]carbonyl]- 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Cabozantinib impurity DX2
Cabozantinib Impurity EXA N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide Cabozantinib Impurity 5 4-Aminoveratrole 4-Amino-2-Chloro-6,7-Dimethoxyquinoline
4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBONITRILE ethyl 4-chloro-5,8-dimethoxyquinoline-3-carboxylate 4-CHLORO-7,8-DIMETHOXYQUINOLINE
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6,7-DIMETHOXY-4-CHLOROQUINOLINE 4-CHLORO-6,7-DIMETHOXYQUINOLINE Quinoline, 4-chloro-6,7-dimethoxy- 4-CHLORO-6,7-DIMETHOXYQUINOLINE(35654-56-9) Cabozantinib 4-Chloroquinoline Impurity 4-Chloro-6,7-dimethoxyquinoline > oro-6,7-dimethoxyquinoL Cabozantinib Impurity 71 4-CHLORO-6,7-DIMETHOXYQUINOLINE ISO 9001：2015 REACH 4-CHLORO-6 7-DIMETHOXYQUINOLINE Cabozantinib Chloro Analog 4-Chloro-6,7-dimethoxyquioline 4-Chloro-6,7-dimethoxy-quinolin 35654-56-9 Quinoline&Isoquinoline 35654-56-9