1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
![1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Structure](CAS/GIF/849217-48-7.gif)
- CAS No.
- 849217-48-7
- Chemical Name:
- 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
- Synonyms
- 1-((4-FL;Cabozantinib impurities4;InterMediate of Cabozantinib;Intermediate2 of Cabozantinib;FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid;1-(4- fluorophenyl formamido) cyclopropanecarboxylic acid;1-{[(4-fluorophenyl)aMino]carbonyl}cyclopropanecarboxylic acid
- CBNumber:
- CB52460100
- Molecular Formula:
- C11H10FNO3
- Molecular Weight:
- 223.2
- MOL File:
- 849217-48-7.mol
- Modify Date:
- 2024/5/15 10:59:15
Melting point | 173.0 to 177.0 °C |
---|---|
Boiling point | 475.2±30.0 °C(Predicted) |
Density | 1.521 |
storage temp. | Sealed in dry,Room Temperature |
solubility | soluble in Methanol |
form | powder to crystal |
pka | 3.48±0.20(Predicted) |
color | White to Almost white |
InChI | InChI=1S/C11H10FNO3/c12-7-1-3-8(4-2-7)13-9(14)11(5-6-11)10(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16) |
InChIKey | PFMAFXYUHZDKPY-UHFFFAOYSA-N |
SMILES | C1(C(NC2=CC=C(F)C=C2)=O)(C(O)=O)CC1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315+H320 | |||||||||
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
HS Code | 2924.29.9500 | |||||||||
NFPA 704 |
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1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemicals (India) | F1083 | 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid | 849217-48-7 | 1G | ₹6000 | 2022-05-26 | Buy |
TCI Chemicals (India) | F1083 | 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid | 849217-48-7 | 5G | ₹19300 | 2022-05-26 | Buy |
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Chemical Properties,Uses,Production
Chemical Properties
White powdery substance.
Uses
1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid is a useful research chemical that can be used as a cabozantinib intermediate.
Synthesis
Cyclopropyl-1,1-dicarboxylic acid(10 g, 77 mmol) in THF (100 mL) was cooled in an ice-water bath, and Triethylamine (8.0 g, 79 mmol) was added dropwise. The temperature of the ice bath during the dropping process is controlled below 10 degrees. The resulting solution was stirred for 30 minutes, and then thionyl chloride (SOCl2, 9.0 g, 76 mmol). Then, dropwise, 4-fluoroaniline (9.0 mL) of THF (30 mL) was added. The ice bath temperature during the whole dripping process is controlled below 10 degrees. The stirring continued for 4 hours, and the reaction was warmed to room temperature. The reaction was diluted with 200 mL of EtOAc And then washed with aqueous NaOH (1.0 M, 50 mL), water (40 mL), and saturated brine (40 mL). The resulting organic solution was dried over Na2SO4, suction filtered, and evaporated to ~ 30 mL. To the resulting viscous liquid was added heptane (200 mL), and a lot of flaky solid precipitated. Filtration and drying gave 1-((4-Fluorophenyl)carbamoyl) cyclopropane carboxylic acid (15.8 g, 93 percent).
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Preparation Products And Raw materials
Raw materials
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