Clostebol
- CAS No.
- 1093-58-9
- Chemical Name:
- Clostebol
- Synonyms
- CLOSTEBOL;Cholostebol;17β-Clostebol;Chlortestosterone;Clostebol VETRANAL;Clostebol Standard;Clostebol USP/EP/BP;ClostebolAcetateBase;4-CHLOROTESTOSTERONE;Clostebol Raw Powder
- CBNumber:
- CB8730750
- Molecular Formula:
- C19H27ClO2
- Molecular Weight:
- 322.87
- MOL File:
- 1093-58-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/4 17:41:45
| Melting point | 188-190° |
|---|---|
| alpha | D20 +148° (CHCl3) |
| Boiling point | 448.4±45.0 °C(Predicted) |
| Density | 1.0514 (estimate) |
| solubility | DMF: 20 mg/mL; DMSO: 30 mg/mL; DMSO:PBS (pH 7.2) (1:10): 0.09 mg/mL; Ethanol: 20 mg/mL |
| form | A crystalline solid |
| pka | 14.99±0.70(Predicted) |
| CAS DataBase Reference | 1093-58-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Chloro-17beta-hydroxyandrost-4-en-3-one(1093-58-9) |
Clostebol Chemical Properties,Uses,Production
Description
Clostebol (Item No. 21168) is an analytical reference standard that is categorized as an androgenic anabolic steroid. Clostebol is a chlorinated form of testosterone (Item Nos. 15645 | ISO60154) that has been used as an athletic performance enhancer and to fatten cattle. It is also detectible in urine. Formulations containing clostebol have been used to treat osteoporosis, anorexia, and certain types of liver disease. Clostebol is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.
Uses
Clostebol is an anabolic steroid. This is a controlled substance.
Synthesis
Clostebol can be synthesized from 4,5-Epoxy-androstan-17β-ol-3-one by acidification with 25% hydrochloric acid.
Procedure：8.50 g epoxide (4,5-Epoxy-androstan-17β-ol-3-one) was dissolved in 150 ml Acetone and treated with 14 ml of 25% hydrochloric
acid. An immediate color shift of the reaction mixture from light yellow to deep blue can be
observed. After stirring for 30 h at room temperature, a complete conversion of the epoxide (4,5-Epoxy-androstan-17β-ol-3-one)
can be monitored by TLC. The reaction mixture was diluted with 400 ml water, leading to the
formation of a blue-black solid precipitating from the solution. After evaporation of acetone, the remaining aqueous solution was extracted several times with
200 ml dichloromethane. The combined organic extracts were washed with saturated sodium
bicarbonate solution and sodium chloride solution before drying over magnesium sulfate.
The crude product was chromatographed on silica gel by using hexane-ethyl acetat (1:1) and
followed by a recrystallization from acetone. The isolated product Clostebol was obtained as
yellowish crystals (4.50 g; 51%).
Clostebol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Orgamine Chemicals(I) Pvt Ltd | +91-9820080281 +91-9820080281 | Maharashtra, India | 451 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt. ltd | +91 8550986868 | Maharashtra, India | 736 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| PT CHEM GROUP LIMITED | China | 35426 | 58 | Inquiry | |
| Apeloa production Co.,Limited | +8619933239880 | China | 853 | 58 | Inquiry |
| ShangHai Anpel Co, Ltd. | 18501792038; 18501792038 | China | 9614 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
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