Cisapride | 81098-60-4

Cisapride Properties

Melting point	109.8 °C
Boiling point	605.4±55.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO: ~30 mg/mL
form	solid
pka	13.01±0.40(Predicted)
color	white
Water Solubility	9.319mg/L(30 ºC)
CAS DataBase Reference	81098-60-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H318

Precautionary statements

P280-P305+P351+P338-P310

Hazard Codes

Xi

Risk Statements

41

Safety Statements

26-39

WGK Germany

2

RTECS

CU9372000

NFPA 704

	0
3		0

Cisapride Chemical Properties,Uses,Production

Description

Cisapride is a gastroprokinetic useful in the treatment of reflux esophagitis, constipation, and a variety of gastro-intestinal motility disorders. Its novel mechanism of action is thought to involve the enhancement of acetylcholine release in the mysenteric plexus of the gut. It is reportedly devoid of CNS and cardiac side-effects.

Chemical Properties

White Solid

Uses

Cisapride Monohydrate is a cardioactive drug that causes prolongation of cardiac repolarization in human; selective serotonin 5-HT4 receptor agonist.

Indications

Cisapride (Propulsid) is serotonin-4 (5-HT4) receptor agonists that stimulate GI motility. Cisapride appears to act by facilitating the release of acetylcholine from the myenteric plexus. It has no antiadrenergic, antidopaminergic, or cholinergic side effects. Following oral administration, peak plasma levels occur in 1.5 to 2 hours; the drug’s half-life is 10 hours.

Definition

ChEBI: The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oeso hageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.

Biological Activity

5-HT 4 receptor agonist and gastrokinetic agent. Stimulates intestinal acetylcholine release, possibly via 5-HT 4 receptor-dependent and -independent mechanisms, leading to increased intestinal motility.

Clinical Use

Cisapride has been successfully used to treat gastroparesis and mild gastroesophageal reflux disease.

Side effects

The most frequent side effect has been diarrhea. A few patients had seizure activity that was reversible after medication was discontinued. Cisapride was pulled from the U. S. market after deaths from drug-associated cardiac arrhythmias, including ventricular tachycardia, ventricular fibrillation, torsades de pointes, and QT prolongation.

Metabolic pathway

Cisapride 14C labeled at the carbonyl carbon and 3H labeled at the fluorophenyl moiety or at the piperidine ring is investigated using some animals. N- Dealkylation at the nitrogen of the piperidine ring, resulting in the main urinary metabolite norcisapride, and aromatic hydroxylation of the fluorinated phenyl ring are the major metabolic pathways in dogs and humans. Norcisapride excretion accounts for 14% of the dose in dogs and 41-45% in humans. Minor metabolic pathways are O-dearylation of the 4- fluorophenyl group and oxidation on the piperidine ring (rat, rabbits and dogs: Lavrijsen et al. (1986)15).

Cisapride Preparation Products And Raw materials

Raw materials

n-Propyl ether Fluorobenzene Benzamide Chloromethyl Benzoate 4-Aminopiperidine

Preparation Products

Cisapride Suppliers

Global( 259)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
Euroasia Trans Continental	+91 22 56349035-36	New Delhi, India	519	47	Inquiry
VASUDHA PHARMA CHEM LTD	+ 91-40-4476 3666	Hyderabad, India	26	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Hebei Guanlang Biotechnology Co,.LTD	+86-19930503253; +8619930503252	China	5835	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry

Supplier	Advantage
OCEAN TRADING CORPORATION	58
Euroasia Trans Continental	47
VASUDHA PHARMA CHEM LTD	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Hebei Guanlang Biotechnology Co,.LTD	58
Capot Chemical Co.,Ltd.	60

Cisapride Spectrum

Cisapride(81098-60-4)¹HNMR

81098-60-4(Cisapride)Related Search:

4-Methoxybenzylchloride Anisole ALTRENOGEST Glycine Propyl butyrate

3-(METHOXYMETHOXY)BENZALDEHYDE 2-Methoxyethanol 4'-Methoxyacetophenone 4-Methoxybenzoic acid Propyl gallate

p-Anisidine 4-Methoxyphenol p-Anisaldehyde (Trifluoromethoxy)benzene Chloroacetic acid

Difluorochloromethane Benzamide 2-METHOXYBENZAMIDE

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(+/-)-4-AMINO-5-CHLORO-N-[1-[(3R*,4S*)-3-(4-FLUOROPHENOXY)PROPYL]-3-METHOXY-4-PIPERIDINYL]-2-METHOXYBENZAMIDE 4-AMINO-5-CHLORO-N-[(3R,4S)-1-[3-(4-FLUOROPHENOXY)PROPYL]-3-METHOXYPIPERIDIN-4-YL]-2-METHOXYBENZAMIDE Alimix Benzamide, 4-amino-5-chloro-N-[1-[(3R,4S)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, rel- cis-2-Methoxy-4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]benzamide Propulsin Risamal T 1341 benzamide,4-amino-5-chloro-n-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperi monohydrate,cis-dinyl)-2-methoxy prepulsid propulsid r51619 CISAPRIDE CISAPRIDE HYDRATE CISAPRIDE MONOHYDRATE (+/-)-cis-4-amino-5-chloro-n-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperidinyl)-2-methoxybenzamide CIS-4-AMINO-5-CHLORO-N-[1-[3-(4-FLUOROPHENOXY)PROPYL]-3-METHOXY-4-PIPERIDINYL]-2-METHOXYBENZAMIDE CIS-4-AMINO-5-CHLORO-N-[1-[3-(4-FLUOROPHENOXY)PROPYL]-3-METHOXY-4-PIPERIDINYL]-2-METHOXYBENZAMIDE, MONOHYDRATE CIPRIL ACENALIN cis-4-Amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-rnethoxybenzamide (+)-R-Cisapride 4-Amino-5-chloro-N-[(3S)-1-[3-(4-fluorophenoxy)propyl]-3α-methoxy-4α-piperidinyl]-2-methoxybenzamide 4-Amino-5-chloro-N-[(3S)-1-[3-(4-fluorophenoxy)propyl]-3α-methoxypiperidine-4α-yl]-2-methoxybenzamide (-)-S-Cisapride 4-Amino-5-chloro-N-[(3R)-1-[3-(4-fluorophenoxy)propyl]-3β-methoxy-4β-piperidinyl]-2-methoxybenzamide 4-Amino-5-chloro-N-[(3R)-1-[3-(4-fluorophenoxy)propyl]-3β-methoxypiperidine-4β-yl]-2-methoxybenzamide Risamol 4-Amino-5-chloro-N-{1[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinyl}-2-methoxy-benzamide 4-Amino-5-chloro-N-{(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide 4-Amino-5-chloro-N-((3S,4R)-1-(3-(4-fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide (±)-4-Amino-5-chloro-N-[1-[(3R*,4S*)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide 4-azanyl-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-piperidin-4-yl]-2-methoxy-benzamide Cisapride, Monohydrate, BP Coordinax rel-4-Amino-5-chloro-N-[1-[(3R,4S)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide (±)-Cisaprid 4-amino-5-chloro-N-[(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidin-1-iumyl]-2-methoxybenzamide Kaudalit Kinestase Pridesia Benzamide,4-amino-5-chloro-N-[1-[(3R,4S)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy- Cisapride USP/EP/BP Cisapride powder rel-4-Amino-5-chloro-N-((3R,4S)-1-(3-(4-fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide CisaprideQ: What is Cisapride Q: What is the CAS Number of Cisapride Q: What is the storage condition of Cisapride Q: What are the applications of Cisapride TIANFU-CHEM_81098-60-4,Cisapride 81098-60-4 281098-60-4 C23H29ClFN3O4 C23H31ClFN3O5 ALDEHYDE API Serotonin receptor Amines Aromatics