ChemicalBook > Product Catalog >Organic Chemistry >Amides >Acyclic polyamines and their derivatives >Tranylcypromine
Tranylcypromine
- CAS No.
- 1986-47-6
- Chemical Name:
- Tranylcypromine
- Synonyms
- TRANS-2-PHENYLCYCLOPROPYLAMINE HYDROCHLORIDE;TRANYLCYPROMINE HYDROCHLORIDE;trans-2-PhenylcyclopropanaMine hydrochloride;trans-2-Phenylcyclopropylamine hydrochloride,97%;SKF-385 HCl;TRANYLCYPROMINE;TIMTEC-BB SBB003859;Tranylcypromine hydr;SKF-385 hydrochloride;Tranylcypromine HCl (2-PCPA)
- CBNumber:
- CB9141768
- Molecular Formula:
- C9H12ClN
- Molecular Weight:
- 169.65
- MOL File:
- 1986-47-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 36/37/38-25-20/21-52-22 | |||||||||
| Safety Statements | 45-36/37/39-26 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214990 | |||||||||
| NFPA 704 |
|
Tranylcypromine price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P8511 | trans-2-Phenylcyclopropylamine hydrochloride | 1986-47-6 | 250MG | ₹5001.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P8511 | trans-2-Phenylcyclopropylamine hydrochloride | 1986-47-6 | 1G | ₹13910.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P8511 | trans-2-Phenylcyclopropylamine hydrochloride | 1986-47-6 | 5G | ₹54882.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P22370 | trans-2-Phenylcyclopropylamine hydrochloride 97% | 1986-47-6 | 1G | ₹11840 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P22370 | trans-2-Phenylcyclopropylamine hydrochloride 97% | 1986-47-6 | 2.5G | ₹23620 | 2022-06-14 | Buy |
Tranylcypromine Chemical Properties,Uses,Production
Chemical Properties
white to light beige powder or chunks
Uses
As with the MAO inhibitor drugs described above, tranylcypromine is also used for depressions that do not respond to other drugs.
General Description
A cell-permeable phenylcyclopropylamine that inhibits the monoamine oxidase and histone demethylase activities, respectively, of MAO A/B (Ki = 101.9 and 16.0 M, respectively) and LSD1/2 (Ki = 242.7 and 180.0 M, respectively), four members of a flavin-dependent amine oxidase family enzymes, by a covalent adduct formation with the enzyme-bound FAD. In addition to preventing LSD1-CoREST (Corepressor of RE1-Silencing Transcription factor) complex-mediated H3K4 demethylation (IC50<2 M), TCP also inhibits LSD1-HCF-1 (Host Cell Factor-1) complex-mediated H3K9 demethylase activity, which is demonstrated to be an essential mechanism for the replication and latent infection of the α-herpesviruses HSV and VZV. The combined treatment of 2 M TCP and 10 M CHIR99061 is reported to enable the reprogramming of Oct4/Klf4-transduced primary HNEKs (Human Neonatal Epidermal Keratinocytes) into iPS (induced Pluripotent Stem) cells, albeit at a 100-time lower efficiency as seen in cultures transduced with 4-TFs (Oct44, Klf4, Sox2, and c-Myc).
Biological Activity
Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO) (K i values are 242, 102 and 16 μ M for LSD1, MAO-A and MAO-B respectively). Inhibits histone demethylation.
Tranylcypromine Preparation Products And Raw materials
Raw materials
Preparation Products
Tranylcypromine Suppliers
Global( 190)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Ajila Chandrahas Enterprise | 08048250329Ext 854 | Karnataka, India | 4 | 58 | Inquiry |
| Tyre Bank | 08069033730Ext 861 | Hyderabad, India | 1 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Ajila Chandrahas Enterprise | 58 |
| Tyre Bank | 58 |
| Alfa Aesar | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Pharma Affiliates | 58 |
| Henan Tianfu Chemical Co.,Ltd. | 55 |
| BOC Sciences | 58 |
1986-47-6(Tranylcypromine)Related Search:
Yohimbine hydrochloride
TRANS-3-BENZYLOXYMETHYLCYCLOBUTANOL
TRANS-3-(TRIMETHYLSILYL)ALLYL ALCOHOL
TRANS-2-PHENYL-1-CYCLOPROPANECARBOXYLIC ACID
TRANS-2-PHENYLCYCLOPROPYLAMINE HYDROCHLO RIDE (TRANYLCYPROMINE HCL),TRANYLCYPROMINE
Tranylcypromine Hemisulfate
CYCLOPROPYLBENZENE
Tranylcypromine
dl-Tranylcypromine,Tranylcypromine (base and/or unspecified salts)
Cyclopropylamine
chevron_left
1of4
chevron_right
rac trans 2-Phenylcyclopropylamine Hydrochloride
trans-2-Phenylcyclopropylamine hydrochloride,Tranylcypromine
Terephathalic acid monoethyl ester
SKF-385 hydrochloride
trans-TranylcyproMine Hydrochloride
rac trans-2-PhenylcyclopropylaMine HCl
(1R,2S)-2-phenylcyclopropanaMine hydrochloride
trans-2-phenylcyclopropylaMine hydrochloride >97% ( GC), %
(1R,2S)-rel-2-PhenylcyclopropanaMine hydrochloride
SKF-385 HCl
trans-2-PhenylcyclopropylaMine hydrochloride 97%
(DL)-Trans-2-phenylcyclopropylamine
Tranylcypromine (2-PCPA) hydrochloride
TRANS-2-PHENYLCYCLOPROPYLAMINE HCL
TIMTEC-BB SBB003859
Tranylcyprominie hydrochloride
trans 2-Amino-1-phenyl-cyclopropane Hydrochloride
TRANYLCYPROMINE
TRANS-2-PHENYLCYCLOPROPANAMINE HCL
Cyclopropanamine, 2-phenyl-, hydrochloride (1:1), (1R,2S)-rel-
Tranylcypromine, HCl - CAS 1986-47-6 - Calbiochem
rac-trans-Tranylcypromine HCl
dl-Tranylcypromine hemisulfate
DL-TRANYLCYPROMINE HEMISULFATE; TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE SALT
Trans-Racemic 2-phenylcyclopropan-1-amine Hydrochloride
Tranylcyprominehydrochloride,(±)-trans-2-Phenylcyclopropylaminehydrochloride
Tranylcypromine ISO 9001：2015 REACH
Tranylcypromine hydr
Tranylcypromine HCl (2-PCPA)
Tranylcypromine hydrochlorideQ: What is
Tranylcypromine hydrochloride Q: What is the CAS Number of
Tranylcypromine hydrochloride Q: What is the storage condition of
Tranylcypromine hydrochloride Q: What are the applications of
Tranylcypromine hydrochloride
(+)-Tranylcypromine D5 HydrochlorideQ: What is
(+)-Tranylcypromine D5 Hydrochloride Q: What is the CAS Number of
(+)-Tranylcypromine D5 Hydrochloride Q: What is the storage condition of
(+)-Tranylcypromine D5 Hydrochloride Q: What are the applications of
(+)-Tranylcypromine D5 Hydrochloride
TRANYLCYPROMINE HYDROCHLORIDE
TRANS-2-PHENYLCYCLOPROPYLAMINE HYDROCHLORIDE
trans-2-PhenylcyclopropanaMine hydrochloride
trans-2-Phenylcyclopropylamine hydrochloride,97%
(1R,2S)-2-phenylcyclopropan-1-amine hydrogen chloride
(1R,2S)-rel-2-phenyl-Cyclopropanamine hydrochloride (1:1)
Tranylcypromine hydrochloride (GMP)
Trans phenylcyclopropylamine hydrochloride
1986-47-6
C9H11NHCl
C6H5C3H4NH2HCl
Enzyme Inhibitors
Enzyme Inhibitors by Enzyme
Enzymes, Inhibitors, and Substrates
Monoamine oxidase inhibitor
Nitrogen Compounds
L to O
Organic Building Blocks
BioChemical
Amine Salts
Biochemicals and Reagents
Building Blocks
Chemical Amines
Amines
Aromatics
Inhibitors
Amine Salts