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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >TGF-beta / Smad >PKC inhibitor >3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione Structure
CAS No.
425637-18-9
Chemical Name:
3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
Synonyms
CS-1479;Dusquetide;Sotrastaurin;Sotrastaurin (AEB071);Glycerol Impurity 111;AEB071; AEB 071; AEB-071;1H-benzo[d][1,2,3]triazol-5-ol;Sotrastaurin - AEB 071 | NVP-AEB 071;3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione;3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione
CBNumber:
CB92510056
Molecular Formula:
C25H22N6O2
Molecular Weight:
438.48
MOL File:
425637-18-9.mol
Modify Date:
2024/7/2 8:55:41
Request For Quotation

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione Properties

Density 1.406
storage temp. Store at -20°C
solubility ≥21.9 mg/mL in DMSO; insoluble in H2O; ≥2.55 mg/mL in EtOH with ultrasonic
form solid
pka 7.39±0.60(Predicted)
color Pink to red

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML3210 Sotrastaurin ≥98% (HPLC) 425637-18-9 5MG ₹8569.2 2022-06-14 Buy
Sigma-Aldrich(India) SML3210 Sotrastaurin ≥98% (HPLC) 425637-18-9 25MG ₹34587.6 2022-06-14 Buy
Product number Packaging Price Buy
SML3210 5MG ₹8569.2 Buy
SML3210 25MG ₹34587.6 Buy

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione Chemical Properties,Uses,Production

Uses

A potent selective pan-PKC inhibitor and highly inhibits PKCθ with a Ki of 0.22 nM.

Definition

ChEBI: A member of the class of maleimides that is maleimide which is substituted at position 3 by an indol-3-yl group and at position 4 by a quinazolin-4-yl group, which in turn is substituted at position 2 by a 4-methylpiperazin-1-yl group. It is a potent and s lective inhibitor of protein kinase C and has been investigated as an immunosuppresant in renal transplant patients.

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione Preparation Products And Raw materials

Raw materials

Preparation Products

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione Suppliers

Global( 124)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49403 58 Inquiry
Hubei Ipure Biology Co., Ltd +8613367258412 China 10326 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 23430 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
CONIER CHEM AND PHARMA LIMITED 58
Hubei Ipure Biology Co., Ltd 58
Career Henan Chemica Co 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione Spectrum

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione(425637-18-9)1HNMR

425637-18-9(3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione)Related Search:

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3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione Sotrastaurin Sotrastaurin (AEB071) 3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione Dusquetide Sotrastaurin - AEB 071 | NVP-AEB 071 CS-1479 AEB071; AEB 071; AEB-071 1H-benzo[d][1,2,3]triazol-5-ol 1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]- 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione USP/EP/BP Glycerol Impurity 111 425637-18-9 Smad TGF-beta Inhibitors