FLECAINIDE ACETATE
- CAS No.
- 54143-56-5
- Chemical Name:
- FLECAINIDE ACETATE
- Synonyms
- FLAC;Apocard;Tambocor;r-818;Ecrinal;Almarytm;Flucarney Acetate;FLECAINIDE ACETATE;Flecainide-d4 Acetate;Flecainide acetate CRS
- CBNumber:
- CB9295801
- Molecular Formula:
- C19H24F6N2O5
- Molecular Weight:
- 474.39
- MOL File:
- 54143-56-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:41
| Melting point | 145-147℃ |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in water and in anhydrous ethanol. It is freely soluble in dilute acetic acid and practically insoluble in dilute hydrochloric acid. |
| form | Solid |
| color | White |
| Water Solubility | Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water. |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H319-H335-H360FD | |||||||||
| Precautionary statements | P201-P202-P301+P312-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-63 | |||||||||
| Safety Statements | 22-26-36/37/39-45-46 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | CV5792550 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933399090 | |||||||||
| NFPA 704 |
|
FLECAINIDE ACETATE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F6777 | Flecainide acetate salt | 54143-56-5 | 25MG | ₹14083.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2921 | Flecainide Acetate pharmaceutical secondary standard, certified reference material | 54143-56-5 | 500MG | ₹18478.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F6777 | Flecainide acetate salt | 54143-56-5 | 100MG | ₹48247.03 | 2022-06-14 | Buy |
FLECAINIDE ACETATE Chemical Properties,Uses,Production
Chemical Properties
White or almost white, very hygroscopic, crystalline powder.
Uses
Flecainide acetate is used as a sodium channel blocker and as an anti-arrhythmic. In general, it is used to regulate heartbeats of the upper heart and lower heart chambers. It can also be used to slow down an overactive heart. It is also useful in the treatment of ventricular tachycardias and ventricular arrhythmias.
Definition
ChEBI: An acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
General Description
Flecainide acetate, N-(2-piperidinylmethyl)-2,5-bis (2,2,2-trifluoroethoxy)benzamide monoacetate(Tambocor), is a class IC antiarrhythmic drug withlocal anesthetic activity; it is a chemical derivative of benzamide.The drug undergoes biotransformation, forming ameta-O-dealkylated compound, whose antiarrhythmic propertiesare half as potent as those of the parent drug, and ameta-O-dealkylated lactam of flecainide with little pharmacologicalactivity. Flecainide acetate is given orally to suppresschronic ventricular ectopy and ventricular tachycardia.It has some limitations because of CNS side effects.
Biological Activity
Open Na + channel blocker that inhibits fast Na + current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.
FLECAINIDE ACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Metrochem API Private Limited | +91-4069069999 +91-4069069999 | Telangana, India | 78 | 58 | Inquiry |
| Solara Active Pharma Sciences Ltd | +91-8046632100 +91-7075706520 | Bangalore, India | 65 | 58 | Inquiry |
| OMSAV Pharma Research Pvt Ltd | +91-9987998884 +91-9987759453 | NaviMumbai, India | 11 | 58 | Inquiry |
| Manus Aktteva Biopharma LLP | 08048250218Ext 800 | Ahmedabad, India | 655 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Esschem Pvt., Ltd. | 91-22-22182485 | Maharashtra, India | 96 | 58 | Inquiry |
| Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group) | 91-22-42361111 | Maharashtra, India | 147 | 58 | Inquiry |
| Ayon PharmaChem | 91-22-28638348 | Maharashtra, India | 303 | 58 | Inquiry |