1,3-Diamino-2-propanol
![1,3-Diamino-2-propanol Structure](CAS/GIF/616-29-5.gif)
- CAS No.
- 616-29-5
- Chemical Name:
- 1,3-Diamino-2-propanol
- Synonyms
- 1,3-DIAMINOPROPAN-2-OL;1,3-DIAMINO-2-HYDROXYPROPANE;Glycerol-α,γ-diamine;1,3-diamino-2-propano;1,3-DIAMINO-2-PROPANOL;2-Propanol, 1,3-diamino-;2-Hydroxypropylenediamine;1,3-Diamino-2-propanol>1,3-DIAMINO-2-HYDROXYPROPAN;1,3-Diamino-2-propanol ,97%
- CBNumber:
- CB9315639
- Molecular Formula:
- C3H10N2O
- Molecular Weight:
- 90.12
- MOL File:
- 616-29-5.mol
- Modify Date:
- 2024/8/24 19:19:26
Melting point | 40-44 °C(lit.) |
---|---|
Boiling point | 235°C |
Density | 1.0352 (rough estimate) |
refractive index | 1.4610 (estimate) |
Flash point | >230 °F |
storage temp. | 2-8°C |
solubility | water: soluble1g/10 mL |
form | Low Melting Solid |
pka | 9.69, 7.93(at 20℃) |
color | White to yellow |
Water Solubility | Very soluble in water. |
BRN | 741859 |
InChI | InChI=1S/C3H10N2O/c4-1-3(6)2-5/h3,6H,1-2,4-5H2 |
InChIKey | UYBWIEGTWASWSR-UHFFFAOYSA-N |
SMILES | C(N)C(O)CN |
CAS DataBase Reference | 616-29-5(CAS DataBase Reference) |
EPA Substance Registry System | 2-Propanol, 1,3-diamino- (616-29-5) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36-37/39 | |||||||||
RIDADR | 3259 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Irritant | |||||||||
TSCA | Yes | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29221990 | |||||||||
NFPA 704 |
|
1,3-Diamino-2-propanol price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | D18609 | 1,3-Diamino-2-propanol 95% | 616-29-5 | 5G | ₹5347.55 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | D18609 | 1,3-Diamino-2-propanol 95% | 616-29-5 | 25G | ₹13628.68 | 2022-06-14 | Buy |
Sigma-Aldrich | 33262 | 1,3-Diamino-2-propanol purum, ≥96.5% (GC) | 616-29-5 | 5G | ₹5921.28 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 33262 | 1,3-Diamino-2-propanol purum, ≥96.5% (GC) | 616-29-5 | 5G | ₹5921.28 | 2022-06-14 | Buy |
Sigma-Aldrich | 33262 | 1,3-Diamino-2-propanol purum, ≥96.5% (GC) | 616-29-5 | 25G | ₹20610.8 | 2022-06-14 | Buy |
1,3-Diamino-2-propanol Chemical Properties,Uses,Production
Description
1,3-Diamino-2-propanol (DAP), also known as 2-hydroxy-1,3-diaminopropane, is a white to yellowish low melting solid. Keep in a cool, well-ventilated place. Avoid prolonged storage periods. Store under inert gas, in a tightly sealed container and at ambient temperatures. 1,3-Diamino-2-propanol is incompatible with acids and strong oxidizing agents and should not be stored or handled in their vicinity.
Chemical Properties
white to yellowish low melting solid
Uses
- 1,3-Diamino-2-propanol is a versatile bidentate diamine ligand which is used in the synthesis of a variety of organometallic compounds.
- It is a precursor to synthesize the fluorogenic dsDNA binder, N1,N3-bis(4-amidinophenyl)propane-1,3-diamine (BAPPA).
- It can also be used as a branching unit in the synthesis of peptide dendrimers.
Preparation
1,3-Diamino-2-propanol is synthesized by reacting Epichlorohydrin with ammonia in alkaline
environment by adding sodium hydroxide. Afterwards, the product
undergoes a series of purification steps.
Application
1,3-diamino-2-propanol (DAPL), a close analog of 1,3-diaminopropane, is an indirect inhibitor of ornithine decarboxylase (ODC). It is administered orally and inhibits ODC activity in the livers of partially hepatectomized rats[1]. It contains amine and hydroxyl groups. Therefore, it can be crosslinked with the carboxyl group via covalent and hydrogen bonds and has been investigated as a diamine monomer in the aqueous phase to fabricate the high-performance RO membrane[2].
Hazard
1,3-Diamino-2-propanoli is a hazardous chemical.
H302 (66.17%): Harmful if swallowed [Warning Acute toxicity, oral]. H314 (66.92%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]. H315 (33.08%): Causes skin irritation [Warning Skin corrosion/irritation]. H317 (66.17%): May cause an allergic skin reaction [Warning Sensitization, Skin]. H318 (66.17%): Causes serious eye damage [Danger Serious eye damage/eye irritation]. H319 (33.08%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]. H335 (34.59%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation.
Purification Methods
Dissolve it in an equal amount of water, shake it with charcoal and distil it at 68o/0.1mm. The distillate solidifies. It is too viscous to be distilled through a packed column. [Beilstein 4 IV 1694.]
References
[1] Raunio H, et al. The inhibition of induction of microsomal monooxygenase activity by 1,3-diamino-2-propanol, an inhibitor of ornithine decarboxylase. Biochemical and Biophysical Research Communications, 1979; 9: 285–290.
[2] Su T, et al. A novel polyamide thin-film nanocomposite reverse osmosis membrane constructed by a 3D multi-layer graphene oxide assembled with 1,3-diamino-2-propanol. Journal of Membrane Science, 2023; 681: 121773.
1,3-Diamino-2-propanol Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
Taizhou Creating Bio-pharm co., ltd. | +8613586099526 | China | 217 | 58 | Inquiry |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12447 | 58 | Inquiry |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5867 | 58 | Inquiry |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20294 | 58 | Inquiry |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18646 | 58 | Inquiry |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
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