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DISTAMYCIN A HYDROCHLORIDE

DISTAMYCIN A HYDROCHLORIDE Structure
CAS No.
6576-51-8
Chemical Name:
DISTAMYCIN A HYDROCHLORIDE
Synonyms
fi6426;herperal;MEN-10399;DISTAMYCIN A HCL;estalimicinaclorhidrato;stallimycinhydrochloride;DISTAMYCIN A HYDROCHLORIDE;distamycin A hydrochloride from*streptomyces dist;DISTAMYCIN A HYDROCHLORIDE FROM*STREPTOM YCES DISTAL;Distamycin A hydrochloride from Streptomyces distallicus
CBNumber:
CB9316227
Molecular Formula:
C22H28ClN9O4
Molecular Weight:
517.97
MOL File:
6576-51-8.mol
Modify Date:
2023/5/4 15:15:38
Request For Quotation

DISTAMYCIN A HYDROCHLORIDE Properties

Melting point 184-187° (Arcamone, 1967). Also reported as 189-193° from ethanol-ethyl acetate (Bialer)
storage temp. −20°C

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Hazard Codes  Xi
Risk Statements  43
Safety Statements  36/37
WGK Germany  3
RTECS  WZ7110000
Toxicity LD50 in mice (mg/kg): 75 i.v.; 500 i.p. (DiMarco)

DISTAMYCIN A HYDROCHLORIDE Chemical Properties,Uses,Production

Originator

Herperal,Farmitalia,Italy,1978

Manufacturing Process

A spore suspension obtained upon washing a culture of Streptomyces distallicus is added to 3,000 ml of a sterile medium consisting of the following:Dextrose 2% Corn steep liquor extract 2% CaCO3 1% (NH4)2SO4 0.3% NaCl 0.3%Fermentation is continued at 28°C for 40 hours at a stirring rate of 150 to 250 rpm and a rate of air flow of 1 to 2 l/min/l of culture medium.
300 ml of a suspension of the vegetative mycelium of this culture are used for inoculating 6,000 ml of a similar sterile culture medium. At this production stage, the culture is kept fermenting for 85 to 100 hours (pH 7.6 at 28°C) at a stirring rate of 350 to 450 rpm and a rate of air flow of 1 to 1.5 l/min/l of culture medium.
To 17 l of a culture obtained by submerged fermentation as mentioned above, siliceous earth is added and the batch is filtered. The mixture of mycelium and the siliceous earth are agitated for 1 hour with 2.5 l of butanol. This treatment is repeated twice. The butanolic extracts are combined, washed with water, evaporated to dryness (about 10 g) and boiled with acetone (80 ml). The 5 g of distamycin is extracted six times with ethanol. The ethanolic extracts are combined, concentrated and filtered through a column containing 70 g of alumina. Elution is carried out with the same solvent. The effluent (central fractions) is collected and evaporated to dryness to yield 0.43 g of pure distamycin A: decomposition point, 183°C to 185°C. The product can be further purified by crystallization from aqueous n-butanol.

Therapeutic Function

Antibiotic

DISTAMYCIN A HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

CORN STEEP LIQUOR D(+)-Glucose

Preparation Products

DISTAMYCIN A HYDROCHLORIDE Suppliers

Global( 20)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21669 55 Inquiry
Alfa Chemistry United States 24072 58 Inquiry
Chem-Impex International, Inc. 800 869-9290 US and Canada only United States 6740 64 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6373 71 Inquiry
3B Scientific Corporation 847.281.9822 United States 6744 47 Inquiry
SERVA Electrophoresis GmbH +49-(0)6221-13840-0 Germany 1142 80 Inquiry
CARBONE SCIENTIFIC CO.,LTD +44(0)870 486 8629 United Kingdom 6682 30 Inquiry
SIGMA-RBI 800 736 3690 (Orders) Switzerland 6913 91 Inquiry
Sinus Biochemistry & Electrophoresis GmbH 0049 6221 82822 0 Germany 621 68 Inquiry
Riedel-de Haen AG 800 558-9160 United States 6825 87 Inquiry
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 55
Alfa Chemistry 58
Chem-Impex International, Inc. 64
Service Chemical Inc. 71
3B Scientific Corporation 47
SERVA Electrophoresis GmbH 80
CARBONE SCIENTIFIC CO.,LTD 30
SIGMA-RBI 91
Sinus Biochemistry & Electrophoresis GmbH 68
Riedel-de Haen AG 87

6576-51-8(DISTAMYCIN A HYDROCHLORIDE)Related Search:

(1-METHYL-1H-PYRROL-2-YL)METHYLAMINE 1H-PYRROLE-2-CARBOXAMIDE Tallimustine Stallimycin 1H-Pyrrole-2-carboxamide, 4-(((4-((((aminoiminomethyl)amino)acetyl)ami no)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-N-(5-(((2-(aminoiminomethy l)-1-methylethyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, d ihydrochloride
DISTAMYCIN A HYDROCHLORIDE METHYL-(1-METHYL-1H-PYRROL-2-YLMETHYL)-AMINE 1H-Pyrrole-2-carboxamide, 4-(((4-((((aminoiminomethyl)amino)acetyl)ami no)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-N-(5-(((3-amino-3-iminopro pyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, dihydrochlorid e N-Methylpyrrole-2-carboxaldehyde propionamidine hydrochloride
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1H-Pyrrole-2-carboxaMide,N-[5-[[(3-aMino-3-iMinopropyl)aMino]carbonyl]-1-Methyl-1H-pyrrol-3-yl]-4-[[[4-(forMylaMino)-1-Methyl-1H-pyrrol-2-yl]carbonyl]aMino]-1-Methyl-,hydrochloride (1:1) N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-me distamycin A hydrochloride from*streptomyces dist N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrole-2-carboxamide monohydrochloride Distamycin A hydrochloride from Streptomyces distallicus MEN-10399 DISTAMYCIN A HYDROCHLORIDE FROM*STREPTOM YCES DISTAL estalimicinaclorhidrato fi6426 herperal stallimycinhydrochloride DISTAMYCIN A HCL DISTAMYCIN A HYDROCHLORIDE 6576-51-8 C22H27N9O4HCl C22H28O4N9Cl Antibiotics A to Z Antibiotics A-F Antibiotics BioChemical