Benznidazole
- CAS No.
- 22994-85-0
- Chemical Name:
- Benznidazole
- Synonyms
- ro71051;radanil;Rochagan;Aids007909;NSC 299972;Ro 07-1051;Aids-007909;Benznidazol;benznidazole;Benzonidazol
- CBNumber:
- CB9390906
- Molecular Formula:
- C12H12N4O3
- Molecular Weight:
- 260.25
- MOL File:
- 22994-85-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/2 22:45:52
| Melting point | 189-192 °C (lit.) |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | methanol: soluble50mg/mL, clear, colorless to yellow |
| pka | 14?+-.0.46(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 0.4g/L(temperature not stated) |
| Merck | 13,1085 |
| BCS Class | 3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NI3340000 | |||||||||
| NFPA 704 |
|
Benznidazole price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 419656 | N-Benzyl-2-nitro-1H-imidazole-1-acetamide 97% | 22994-85-0 | 1G | ₹17872.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 419656 | N-Benzyl-2-nitro-1H-imidazole-1-acetamide 97% | 22994-85-0 | 1G | ₹17872.08 | 2022-06-14 | Buy |
Benznidazole Chemical Properties,Uses,Production
Description
Benznidazole is the second of the drugs approved for treatment of Chagas' disease. Like nifurtimox, it is effective against the circulating form of Trypanosoma cruzi during the acute phase of the disease, but also like nifurtimox, it is ineffective during the chronic stage of the disease.
Uses
Benznidazole (BNZ) is traditionally used to treat Chagas disease caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, Nifurtimox and Benznidazole, are toxic and present sever e side effects.
Definition
ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.
Antimicrobial activity
It exhibits antiprotozoal activity, particularly against Trypanosoma cruzi.
General Description
N-Benzyl-2-nitro-1H-imidazole-1-acetamide (Benznidazole) is a nitro-heterocyclic compound. It is widely employed drug for the treatment of Chagas disease. It exhibits three polymorphic forms..
Pharmaceutical Applications
A synthetic 2-nitroimidazole, formulated for oral administration. Solubility in water 400 mg/L.
Mechanism of action
Studies suggest that benznidazole does not catalyze the formation of ROS and, therefore, has a mechanism of action different from that of nifurtimox. It has been proposed that benznidazole undergoes an one-electron transfer to the nitro group, which in turn dismutates to give back the nitroimidazole and a nitrosoimidazole. The latter product may then undergo an electrophilic addition to trypanothione, which leads to depletion of trypanothione, an essential enzyme system in the Trypanosoma cruzi.
Pharmacokinetics
Oral bioavailability :High
Cmax 100 mg oral ：2.2–2.8 mg/L after 3–4 h
Plasma half-life：10.5–13.6 h
Volume of distribution：c. 0.56 L/kg
Plasma protein binding： c. 44%
The 2-nitro group undergoes reduction to the amine and hydrolysis to the hydroxy derivative.
Clinical Use
Benznidazole is used in treatment of South American trypanosomiasis (Chagas disease).
Side effects
Adverse effects are more common in the elderly and include nausea, vomiting, abdominal pain, peripheral neuropathy and severe skin reactions.
Benznidazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Sigma Audley | +86-18336680971 +86-18126314766 | China | 497 | 58 | Inquiry |
| Shanghai Aosiris new Material Technology Co., LTD | 86-15139564871 +8615139564871 | China | 264 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9626 | 58 | Inquiry |