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8-M-PDOT

8-M-PDOT Structure
CAS No.
134865-70-6
Chemical Name:
8-M-PDOT
Synonyms
AH 002;8-M-PDOT;8 M PDOT,8MPDOT;8-METHOXY-2-PROPIONAMIDOTETRALIN;Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-
CBNumber:
CB9487996
Molecular Formula:
C14H19NO2
Molecular Weight:
233.31
MOL File:
134865-70-6.mol
Modify Date:
2024/7/2 8:55:42
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8-M-PDOT Properties

Boiling point 447.8±45.0 °C(Predicted)
Density 1.09±0.1 g/cm3(Predicted)
storage temp. Store at RT
solubility Soluble to 50 mM in ethanol and to 100 mM in DMSO
form Powder
pka 15.87±0.20(Predicted)
color White to off-white

8-M-PDOT Chemical Properties,Uses,Production

Description

8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.

Biological Activity

Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively.

8-M-PDOT Preparation Products And Raw materials

Raw materials

Preparation Products

8-M-PDOT Suppliers

Global( 29)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9708 58 Inquiry
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4398 58 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6373 71 Inquiry
MOLEKULA Ltd. +44 (0) 1747 831066 United Kingdom 6152 66 Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15848 69 Inquiry
Tocris Bioscience +44 (0) 117 916 3333 United Kingdom 5729 77 Inquiry
ApexBio Technology + 1-832-696-8203 United States 6254 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Cayman Chemical Company 81
Shanghai EFE Biological Technology Co., Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Service Chemical Inc. 71
MOLEKULA Ltd. 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Tocris Bioscience 77
ApexBio Technology 58

134865-70-6(8-M-PDOT)Related Search:

1-(2-METHOXY-PHENYL)-2-BUTANAMINE 2-Amtt 8-METHOXY-2-AMINOTETRALIN 8-M-PDOT Methoxyphenamine
8-METHOXY-2-PROPIONAMIDOTETRALIN 8-M-PDOT AH 002 8 M PDOT,8MPDOT Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)- 134865-70-6