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Dihydrostreptomycin

CAS No.: 128-46-1

Chemical Name:: Dihydrostreptomycin

Synonyms: DHSM;dhms;abiocine;vibriomycin;DIHYDROSTREPTOMYCIN;dihydro-streptomyci;DihydroestreptoMycin Sulfate;Benzimidazole, 2-cyanomethyl;dihydrostreptomycine sulphate;Dihydrostreptomycin USP/EP/BP

CBNumber:: CB9665040

Molecular Formula:: C21H41N7O12

Molecular Weight:: 583.59

MOL File:: 128-46-1.mol

MSDS File:: SDS

Modify Date:: 2024/3/16 15:39:10

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Dihydrostreptomycin Properties

Melting point	>300 °C
Boiling point	641.09°C (rough estimate)
Density	1.3963 (rough estimate)
refractive index	1.6800 (estimate)
pka	pKa 7.8 (Uncertain)

Dihydrostreptomycin Chemical Properties,Uses,Production

Description

Dihydrostreptomycin was first synthesized by Parke Davis Co. in 1946by the reduction of streptomycin. Naturally occurring dihydrostreptomycin was found in the culture broth of Streptomyces humidus by Takeda Chemicals Industries in 1957. Its hydrochloride or sulfate is more easily crystallized and more stable under alkaline conditions than streptomycin. Dihydrostreptomycin has been used for therapy of tuberculosis, but because it has a higher ototoxicity than streptomycin its use is now restricted to animal therapy.

Uses

Antibacterial.

World Health Organization (WHO)

Dihydrostreptomycin, a derivative of the aminoglycoside antibiotic streptomycin with similar antibacterial activity, was first synthesized in 1947 and subsequently used in the treatment of tuberculosis and gram-negative infections. Preparations for systemic use have been widely withdrawn as a result of concern regarding their severe ototoxicity. Dihydrostreptomycin is poorly absorbed from the gastrointestinal tract. It remains available in oral preparations in some countries.

Safety Profile

Poison by intravenous and intramuscular routes. Moderately toxic by subcutaneous and intraperitoneal routes. Human teratogenic effects by unspecified route: developmental abnormahties of the eye and ear. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A derivative of streptomycin; has anesthetic properties. When heated to decomposition it emits toxic fumes of NOx

Dihydrostreptomycin Preparation Products And Raw materials

Raw materials

Hydrogen Streptomycin sulfate

Preparation Products

Dihydrostreptomycin Suppliers

Global( 45)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
SIMAGCHEM CORP	+86-13806087780	China	17367	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	China	9030	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
GIHI CHEMICALS CO.,LIMITED	+8618058761490	China	49999	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
BOC Sciences	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
LEAPCHEM CO., LTD.	58

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DIHYDROSTREPTOMYCIN Dihydrostreptomycin (base and/or unspecified salts) 2-[(1S,3R,4S,5R,6R)-5-(Diaminomethylideneamino)-2-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylaminooxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-3,4,6-trihydroxycyclohexyl]guanidine Acetonitrile, 2-benzimidazolyl- Benzimidazole, 2-cyanomethyl 4-O-[2-O-[2-(Methylamino)-2-deoxy-α-L-glucopyranosyl]-5-deoxy-3-hydroxymethyl-α-L-lyxofuranosyl]-N,N'-bis(aminoiminomethyl)-D-streptamine DHSM DihydroestreptoMycin Sulfate 2)-O-5-deoxy-3-C-(hydroxyMethyl)-a-L-lyxofuranosyl-(1® 4)-N1,N3-bis(aMinoiMinoMethyl)- D-StreptaMine,O-2-deoxy-2-(MethylaMino)-a-L-glucopyranosyl-(1® dihydrostreptomycine sulphate DihydrostreptomycineSulphateSterileUsp26 D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1?4)-N,N-bis(aminoiminomethyl)- abiocine dhms dihydro-streptomyci vibriomycin 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)- Dihydrostreptomycin USP/EP/BP 128-46-1 C21H41N7O12