Chlormadinone acetate
- CAS No.
- 302-22-7
- Chemical Name:
- Chlormadinone acetate
- Synonyms
- CMA;Chlormadinone;CHLOROMADINON 17-ACETATE;17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione;6-Chloro-3,20-dioxopregna-4,6-dien-17-yl acetate;Cero;st155;Retex;ST 155;Verton
- CBNumber:
- CB9673089
- Molecular Formula:
- C23H29ClO4
- Molecular Weight:
- 404.93
- MOL File:
- 302-22-7.mol
- Modify Date:
- 2024/7/2 8:55:42
| Melting point | 212°C |
|---|---|
| alpha | D +6° (c = 1 in CHCl3) |
| Boiling point | 512.5±50.0 °C(Predicted) |
| Density | 1.1345 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Light Yellow |
| λmax | 285nm(EtOH)(lit.) |
| Merck | 14,2102 |
| BRN | 2633614 |
| NIST Chemistry Reference | Chlormadinone acetate(302-22-7) |
| EPA Substance Registry System | Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-chloro- (302-22-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H351-H360 |
| Precautionary statements | P202-P405-P501-P201-P280-P308+P313-P281 |
| Hazard Codes | T |
| Risk Statements | 60-61-40-48 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | TU3750000 |
| HS Code | 29372390 |
| Toxicity | mouse,LD50,intraperitoneal,3gm/kg (3000mg/kg),ENDOCRINE: ADRENAL CORTEX HYPOPLASIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 571, 1977. |
Chlormadinone acetate Chemical Properties,Uses,Production
Description
Chlormadinone acetate is a synthetic progestin. It binds to progesterone, androgen, and glucocorticoid receptors in vitro (Kis = 2.5, 3.8, and 16 nM, respectively, for the human receptors). Chlormadinone acetate increases the number of endometrial glands and uterine weight in β-estradiol-primed rabbits when administered at a dose of 45 μg/kg per day for five days. Chlormadinone acetate reduces testosterone-induced increases in the seminal vesicle weight of castrated male rats when administered at doses of 4.6 and 21.5 mg/kg per day for eight days.
Chemical Properties
Crystalline Solid
World Health Organization (WHO)
Chlormadinone acetate, a synthetic progestogen, was introduced in 1965 as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, chlormadinone acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and chlormadinone remains available in some countries for contraceptive purposes. In some instances it is indicated for treatment of progesterone deficiency and endometriosis, and of irregular uterine bleeding due to fibroids. (Reference: (WHODI) WHO Drug Information, 84.1, 5, 1984)
Safety Profile
Suspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Human maternal and reproductive effects by ingestion, intramuscular, and possibly other routes: ovary, uterus, cervix, vagina, and fallopian tube changes; menstrual cycle changes or disorders; changes in ferthty; and other unspecified female effects. A human teratogen that causes developmental abnormalities of the endocrine system in the fetus. Experimental teratogenic and reproductive effects. An oral contraceptive. When heated to decomposition it emits toxic fumes of Cl-.
Chlormadinone acetate Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Vijaya Pharma And Life Science | +91-8939866271 +91-8939866271 | Tamil Nadu, India | 320 | 58 | Inquiry |
| Kebee Pharmachemie Pvt., Ltd. | 91-22-28328669 | Maharashtra, India | 65 | 58 | Inquiry |
| Indogulf Group | 91-22-23455220 | Maharashtra, India | 249 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Merit International | 91-22-40150081 | Maharashtra, India | 226 | 58 | Inquiry |
| Cambrex Corporation (Zenara) | +91 40 27260848 | Hyderabad, India | 25 | 58 | Inquiry |
| Ralington Pharma. | 91-79-48911722 | Gujarat, India | 311 | 58 | Inquiry |
| AVIK PHARMACEUTICAL LIMITED | +91-22-67685000 | New Delhi, India | 54 | 58 | Inquiry |
| Dharmanandan Export Pvt., Ltd. | 91-79-48402200 | Gujarat, India | 161 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Ralington Pharma | 58 |
| Vijaya Pharma And Life Science | 58 |
| Kebee Pharmachemie Pvt., Ltd. | 58 |
| Indogulf Group | 58 |
| Pharma Affiliates | 58 |
| Merit International | 58 |
| Cambrex Corporation (Zenara) | 58 |
| Ralington Pharma. | 58 |
| AVIK PHARMACEUTICAL LIMITED | 58 |
| Dharmanandan Export Pvt., Ltd. | 58 |
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