Chlormadinone acetate
Chlormadinone acetate
- CAS:
- 302-22-7
- MF:
- C23H29ClO4
- MW:
- 404.93
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Company Type
Properties
- Melting point:
- 212°C
- alpha
- D +6° (c = 1 in CHCl3)
- Boiling point:
- 512.5±50.0 °C(Predicted)
- Density
- 1.1345 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Light Yellow
- λmax
- 285nm(EtOH)(lit.)
- Merck
- 14,2102
- BRN
- 2633614
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Danger
- Hazard statements
- H351-H360
- Precautionary statements
- P202-P405-P501-P201-P280-P308+P313-P281
- Hazard Codes
- T
- Risk Statements
- 60-61-40-48
- Safety Statements
- 53-22-36/37/39-45
- WGK Germany
- 3
- RTECS
- TU3750000
- HS Code
- 29372390
- Toxicity
- mouse,LD50,intraperitoneal,3gm/kg (3000mg/kg),ENDOCRINE: ADRENAL CORTEX HYPOPLASIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 571, 1977.
Use
Chlormadinone acetate, a synthetic progestogen, was introduced in 1965 as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, chlormadinone acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and chlormadinone remains available in some countries for contraceptive purposes. In some instances it is indicated for treatment of progesterone deficiency and endometriosis, and of irregular uterine bleeding due to fibroids. (Reference: (WHODI) WHO Drug Information, 84.1, 5, 1984)
19 India supplier list of "Chlormadinone acetate "
- Product Name:Chlormadinone acetate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Chlormadinone acetate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Tamil Nadu,INDIA
- Product Name:Chlormadinone
- Products Intro:Brand:synzeal | Product Number:100234222
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:Chlormadinone acetate
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Chlormadinone acetate
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Chlormadinone acetate
- Company Type: Reagent
- Country/Region: Andhra Pradesh,INDIA
- Product Name:Chlormadinone acetate
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA