Monensin
- CAS No.
- 17090-79-8
- Chemical Name:
- Monensin
- Synonyms
- MONENSIN SODIUM;a3823a;monelan;MONENSIN;Romensin;elancoban;Monensin A;MONENSIN NA;Monensin 20%;monensicacid
- CBNumber:
- CB9748019
- Molecular Formula:
- C36H62O11
- Molecular Weight:
- 670.87
- MOL File:
- 17090-79-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/12/18 14:15:30
Melting point | 103-105°C |
---|---|
alpha | D +47.7° |
Boiling point | 608.24°C (rough estimate) |
Density | 1.0773 (rough estimate) |
refractive index | 1.5465 (estimate) |
storage temp. | 2-8°C |
pka | 6.6 (in 66% DMF) |
CAS DataBase Reference | 17090-79-8(CAS DataBase Reference) |
EPA Substance Registry System | Monensin (17090-79-8) |
SAFETY
Risk and Safety Statements
Hazard Codes | T |
---|---|
Risk Statements | 25 |
Safety Statements | 36/37/39-45 |
WGK Germany | 3 |
RTECS | JH2830000 |
Hazardous Substances Data | 17090-79-8(Hazardous Substances Data) |
Toxicity | LD50 of monensin complex in mice, chicks (mg/kg): 43.8 ± 5.2, 284 ± 47 orally (Haney, Hoehn) |
Monensin Chemical Properties,Uses,Production
Description
Monensin was found in the mycelium of Streptomyces cinnamonensis by Eli Lilly & Co. in 1967 in the course of screening for anticoccidial and growth-promoting substances for cattle, swine, and chickens. It shows antiprotozoal, antibacterial, and antifungal activities, as well as anticoccidial activity. Monensin is widely used to treat such infections and as a feed additive to promote the growth of livestock.
Chemical Properties
Crystallin Solid
Uses
Monensin A is a polyether antibiotic first isolated from Streptomyces cinnamonensis in 1967. Monensin A is a broad-spectrum anticoccicidial antibiotic, also exhibiting antifungal and antiviral activity. Monensin A forms complexes with monovalent cations such as Li+, Na+, K+, Rb+, Ag+ and Tl+ and is thus able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport and is used in animals to prevent coccidiosis, promote growth and prevent bloat. Derivatives of monensin, monensin methyl ester and particularly monensin decyl ester, are used in ion selective electrodes.
Safety Profile
Poison by ingestion and intraperitoneal routes. An eye and skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Monensin Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
Pandora Industries Private Limited | 08048966804 | Delhi, India | 9 | 58 | Inquiry |
SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6514 | 58 | Inquiry |
Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | China | 900 | 58 | Inquiry |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5889 | 58 | Inquiry |
shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 | China | 294 | 58 | Inquiry |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20267 | 58 | Inquiry |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | China | 1143 | 58 | Inquiry |