Monensin manufacturers and suppliers in india

Monensin

Properties

Melting point:: 103-105°C

alpha: D +47.7°

Boiling point:: 608.24°C (rough estimate)

Density: 1.0773 (rough estimate)

refractive index: 1.5465 (estimate)

storage temp.: 2-8°C

pka: 6.6 (in 66% DMF)

Safety Information

Hazard Codes: T

Risk Statements: 25

Safety Statements: 36/37/39-45

WGK Germany: 3

RTECS: JH2830000

Toxicity: LD50 of monensin complex in mice, chicks (mg/kg): 43.8 ± 5.2, 284 ± 47 orally (Haney, Hoehn)

Use

Monensin A is a polyether antibiotic first isolated from Streptomyces cinnamonensis in 1967. Monensin A is a broad-spectrum anticoccicidal antibiotic, also exhibiting antifungal and antiviral activity. Monensin A forms complexes with monovalent cations such as Li+, Na+, K+, Rb+, Ag+ and Tl+ and is thus able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport and is used in animals to prevent coccidiosis, promote growth and prevent bloat. Derivatives of monensin, monensin methyl ester and particularly monensin decyl ester, are used in ion selective electrodes.