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4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID Structure
CAS No.
102121-60-8
Chemical Name:
4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID
Synonyms
cd336;AM 580;CS-1051;l)amino-;ro40-6055;NSC 608001;AM580 (CD336);AM-580;AM 580;CD336; NSC608001; RO 40-6055;4-(1,1,4,4-Tetramethyltetralin-6-ylcarbonylamino)benzoic acid;4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CA...
CBNumber:
CB9781234
Molecular Formula:
C22H25NO3
Molecular Weight:
351.44
MOL File:
102121-60-8.mol
Modify Date:
2023/6/30 15:45:59
Request For Quotation

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID Properties

Melting point 265-267℃
Boiling point 485.24°C (rough estimate)
Density 1.154
refractive index 1.5614 (estimate)
storage temp. -20°C
solubility Soluble in DMSO (20mg/ml) or ethanol (10mg/ml).
form White to off-white solid.
pka 4.28±0.10(Predicted)
color Off-white
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

WGK Germany  3
RTECS  DH6834890
HS Code  2924.29.7790

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A8843 AM580 ≥98% (HPLC) 102121-60-8 5MG ₹21465.98 2022-06-14 Buy
TCI Chemicals (India) A3082 AM580 102121-60-8 5MG ₹2600 2022-05-26 Buy
TCI Chemicals (India) A3082 AM580 102121-60-8 25MG ₹7800 2022-05-26 Buy
TCI Chemicals (India) A3082 AM580 102121-60-8 100MG ₹17800 2022-05-26 Buy
Product number Packaging Price Buy
A8843 5MG ₹21465.98 Buy
A3082 5MG ₹2600 Buy
A3082 25MG ₹7800 Buy
A3082 100MG ₹17800 Buy

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID Chemical Properties,Uses,Production

Uses

Retinoid derivative used for gene expression studies of leukemia-retinoic acid receptor (PHL-RAR) cell line differentiation. AM 580 inhibits tumor proliferation by reducing the level of RARγ and activates RAR β. This receptor increases the expression of disintegrin and metalloprotease.

Definition

ChEBI: An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.

General Description

AM580 is a retinobenzoic derivative and a RAR-α (retinoic acid receptor-α) agonist. It stimulates the maturation of granulocytes in NB4 promyelocytic leukemia cell line and APL (acute promyelocytic leukemia) blasts. AM580 suppresses endometrial cancer cell proliferation.

Biological Activity

An analog of retinoic acid that acts as a selective RAR α agonist (EC 50 values are 0.3, 8.6 and 13 nM for RAR α , RAR β and RAR γ respectively). Significantly induces IL-4, IL-5 and IL-13 and inhibits IL-12 and IFN γ synthesis, and induces cell differentiation with over 7 times the activity of retinoic acid in vitro .

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID Suppliers

Global( 133)Suppliers
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A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
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A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
Career Henan Chemica Co 58
Zhejiang J&C Biological Technology Co.,Limited 58
Labnetwork lnc. 58
InvivoChem 58
Hefei TNJ Chemical Industry Co.,Ltd. 58

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID Spectrum

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID(102121-60-8)1HNMR

102121-60-8(4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID)Related Search:

TCPOBOP Mifepristone Troglitazone Ro 41-5253 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoicacid
4-N-BUTYLBENZYLAMINE 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene 4-N-BUTYLBENZAMIDE 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene (5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTH-2-YL)METHYLAMINE
1-(3-tert-butylphenyl)methanamine 4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID 5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENECARBALDEHYDE N,5,5,8,8-PENTAMETHYL-(5,6,7,8-TETRAHYDRONAPHTH-2-YLMETHYL)AMINE 4-[(4-methylbenzyl)amino]benzoic acid
C-(5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-METHYLAMINE 4-PENTYLBENZYLAMINE 2-(aminopropyl-1-oxyl)-4-((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido)benzoic acid
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4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid NSC 608001 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid benzoicacid,4-((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbony cd336 l)amino- ro40-6055 AM 580 4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID 2-Naphthalenecarboxamide,5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-N-3-quinolinyl- Benzoic acid,4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]- 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)benzoic acid 4-((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl)aminobenz 4-(1,1,4,4-Tetramethyltetralin-6-ylcarbonylamino)benzoic acid 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-ylcarbonylamino)benzoic acid 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphthalen)-2-yl]carbonylamino]benzoic acid AM580 (CD336) CS-1051 AM-580;AM 580;CD336; NSC608001; RO 40-6055 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid 4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CA... inhibit,Inhibitor,NSC-608001,Retinoic acid receptors,CD-336,RAR/RXR,AM 580,CD 336,AM-580,Autophagy,NSC 608001,AM580,Retinoid X receptors 4-((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido)benzoi 102121-60-8 PPAR and RXR Regulators Gene Regulation and Expression Cell Biology Cell Signaling and Neuroscience BioChemical Intracellular receptor