4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID
![4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID Structure](/CAS/GIF/102121-60-8.gif)
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- ₹2600 - ₹21465.98
- Product name: 4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID
- CAS: 102121-60-8
- MF: C22H25NO3
- MW: 351.44
- EINECS:
- MDL Number:MFCD00673916
- Synonyms:4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid;NSC 608001;4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid;benzoicacid,4-((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbony ;cd336 ;l)amino- ;ro40-6055 ;AM 580
4 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
- TCI Chemicals (India)
Package
- 5MG
- 25MG
- 100MG
- ManufacturerSigma-Aldrich(India)
- Product numberA8843
- Product descriptionAM580 ≥98% (HPLC)
- Packaging5MG
- Price₹21465.98
- Updated2022-06-14
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberA3082
- Product descriptionAM580
- Packaging100MG
- Price₹17800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberA3082
- Product descriptionAM580
- Packaging25MG
- Price₹7800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberA3082
- Product descriptionAM580
- Packaging5MG
- Price₹2600
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A8843 | AM580 ≥98% (HPLC) | 5MG | ₹21465.98 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A3082 | AM580 | 100MG | ₹17800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A3082 | AM580 | 25MG | ₹7800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A3082 | AM580 | 5MG | ₹2600 | 2022-05-26 | Buy |
Properties
Melting point :265-267℃
Boiling point :485.24°C (rough estimate)
Density :1.154
refractive index :1.5614 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (20mg/ml) or ethanol (10mg/ml).
form :White to off-white solid.
pka :4.28±0.10(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :485.24°C (rough estimate)
Density :1.154
refractive index :1.5614 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (20mg/ml) or ethanol (10mg/ml).
form :White to off-white solid.
pka :4.28±0.10(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
AM580 is a retinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC50 = 0.36 nM) compared to RARβ (Kd = 131 nM; AC50 = 24.6 nM) and RARγ (Kd = 450 nM; AC50 = 27.9 nM). It demonstrates greater specific binding to RARα compared to retinoic acid , which exhibits little selectivity across RARα, β, or γ. AM580 has been used in combination with the GSK3β inhibitor CHIR99021 to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm. It can also inhibit the proliferation of various tumor cells, inhibiting survival signaling pathways and inducing apoptosis.Related product price
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