ナファモスタットメシル酸塩 化学特性,用途語,生産方法
外観
白色~ほとんど白色粉末~結晶
用途
合成トロンビン剤です。セリ
ンプロテアーゼを阻害し、血液凝固抑制作用
を示します。
効能
抗凝固薬, 抗線溶薬, セリンプロテアーゼ阻害薬
商品名
フサン (日医工)
説明
Nafamostat mesylate is a protease inhibitor useful in the treatment of acute pancreatitis. It has anticomplement,
anticoagulant, antikallikrein and other activities, and thus may have additional
utility in the treatment of autoimmune diseases and disseminated intravascular coagulation.
化学的特性
Tan to pale orange solid
生物活性
Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
合成
By p-guanidinobenzoic acid hydrochloride, 6-amidino groups-beta naphthal, 4,5-dicyano imidazole, methylene dichloride mix, 0-5 ℃ is stirred 1 hour, then improve temperature to 18-22 ℃, insulation reaction 8-12h, filters washed with dichloromethane, gained solid is 2 with methylsulfonic acid adjust pH, obtains nafamostat mesylate.
ナファモスタットメシル酸塩 上流と下流の製品情報
原材料
準備製品