Methyl 4-chloropicolinate
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Methyl 4-chloropicolinate 속성
- 녹는점
- 50-52
- 끓는 점
- 105-111 °C(Press: 2-3 Torr)
- 밀도
- 1.294±0.06 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- -0.25±0.10(Predicted)
- 색상
- 미색부터 베이지까지
- InChI
- InChI=1S/C7H6ClNO2/c1-11-7(10)6-4-5(8)2-3-9-6/h2-4H,1H3
- InChIKey
- VTENWIPSWAMPKI-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC=CC(Cl)=C1
- CAS 데이터베이스
- 24484-93-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
Methyl 4-chloropicolinate C화학적 특성, 용도, 생산
화학적 성질
Brown Solid용도
Methyl 4-Chloropicolinate (cas# 24484-93-3) is a compound useful in organic synthesis.생산 방법
The starting material 2-picolinic acid was treated with SOCl2 to generate 4-chloropicolinoyl chloride, and then esterification with MeOH resulted in the formation of methyl 4-chloropicolinate.Synthesis Reference(s)
Synthetic Communications, 26, p. 2017, 1996 DOI: 10.1080/00397919608003557Synthesis
To a suspension of 4-chloropyridine-2-carboxylic acid (4.5 g, 29.0 mmol) in methylene chloride (120 mL) was added oxalyl chloride (3.0 mL, 1.2 eq) under Ar2. The reaction was cooled to 0° C., and 500 uL of DMF was added. A large amount of gas was generated in situ. The reaction was stirred at room temperature for 1.5 h and then concentrated. Dry MeOH (50 mL) was added to the crude acyl chloride residue. The reaction was stirred at room temperature for 0.5 h, then quenched with NaHCO3 (5%) to neutral, extracted with EtOAc, and washed with brine. The combined organics were dried over MgSO4, filtered, and concentrated in vacuo to give 5.0 g of a crude solid, which was triturated with 5% EtOAc/hexane to give Methyl 4-chloropicolinate as a light yellow solid (4.5 g, 90%).
Methyl 4-chloropicolinate 준비 용품 및 원자재
원자재
4-Chloropyridine-2-carboxylic acid
4-Chloro-pyridine-2-carbonyl chloride
2-PYRIDINECARBOXYLICACID CHLORIDE
피콜린산
Methyl picolinate
메틸4,6-디클로로피리딘-2-카르복실레이트
메틸알콜
염화 티오닐
준비 용품
Methyl 4-chloropicolinate 공급 업체
글로벌( 479)공급 업체
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