SULFAPHENAZOLE

SULFAPHENAZOLE 구조식 이미지
카스 번호:
526-08-9
상품명:
SULFAPHENAZOLE
동의어(영문):
SP;TFF2;Sulfabid;Sulfaphenazol;Sulphaphenazole;Sulfaphenylpyrazole;SML1;Orisul;Inamil;Isarol
CBNumber:
CB4160540
분자식:
C15H14N4O2S
포뮬러 무게:
314.36
MOL 파일:
526-08-9.mol
MSDS 파일:
SDS

SULFAPHENAZOLE 속성

녹는점
179-183 °C
끓는 점
541.9±56.0 °C(Predicted)
밀도
1.39
굴절률
1.6440 (estimate)
저장 조건
2-8°C
용해도
클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
pKa 5.71(H2O t = 25 I = 0.05) (Uncertain)
색상
흰색에서 밝은 노란색

안전

안전지침서 24/25
WGK 독일 2
RTECS 번호 DA9520000
HS 번호 29339900
독성 LD50 orally in mice: 5800 mg/kg (Seki)

SULFAPHENAZOLE C화학적 특성, 용도, 생산

개요

CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme’s activity can lead to adverse drug reactions. Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Kis = 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

화학적 성질

White to off-white powder

정의

ChEBI: A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.

Purification Methods

Crystallise it from EtOH or aqueous EtOH. [Schmidt & Druey Helv Chim Acta 41 309 1958, Beilstein 25 III/IV 2029.]

SULFAPHENAZOLE 준비 용품 및 원자재

원자재

준비 용품


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