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4-Nitroacetophenone

4-Nitroacetophenone 구조식 이미지

카스 번호:: 100-19-6

상품명:: 4-Nitroacetophenone

동의어(영문):: 1-(4-NITROPHENYL)ETHAN-1-ONE;Nitroacetophenone;1-(4-nitrophenyl)ethanone;PNAP;P-NITROACETOPHENONE;NSC 41590;Bromo-2’AURORA KA-7140;AKOS BBS-00003219;p-Nitroacetophenon

CBNumber:: CB5118997

분자식:: C8H7NO3

포뮬러 무게:: 165.15

MOL 파일:: 100-19-6.mol

MSDS 파일:: SDS

속성

안전

MSDS

용도

공급 업체 369

4-Nitroacetophenone 속성

녹는점: 75-78 °C(lit.)

끓는 점: 202 °C(lit.)

밀도: 1.3450 (rough estimate)

굴절률: 1.5468 (estimate)

인화점: 201-202°C

저장 조건: Sealed in dry,Room Temperature

물리적 상태: 결정성 분말

색상: 노란색

수용성: 물에 불용성.

BRN: 607777

InChIKey: YQYGPGKTNQNXMH-UHFFFAOYSA-N

CAS 데이터베이스: 100-19-6(CAS DataBase Reference)

NIST: Acetophenone, 4'-nitro-(100-19-6)

EPA: 4-Nitroacetophenone (100-19-6)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn
위험 카페고리 넘버	36-22
안전지침서	22-24/25
WGK 독일	3
RTECS 번호	AM9627000
위험 참고 사항	Harmful
HS 번호	29147090

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H301	삼키면 유독함	급성 독성 물질 - 경구	구분 3	위험		P264, P270, P301+P310, P321, P330,P405, P501
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P321	(…) 처치를 하시오.
P405	밀봉하여 저장하시오.
P501	...에 내용물 / 용기를 폐기 하시오.

NFPA 704

	0
1		0

4-Nitroacetophenone MSDS

1-(4-nitrophenyl)ethanone

4-Nitroacetophenone C화학적 특성, 용도, 생산

화학적 성질

The pure product is pale yellow crystal or needle crystal. Soluble in hot ethanol, ether and benzene, insoluble in water. 4-Nitroacetophenone is the raw material for the manufacture of synthomycin and chloramphenicol.

용도

4''-Nitroacetophenone is used as a reagent in the synthesis of 4-Nitroacetophenone thiosemicarbazone derivatives and their copper(II) complexes which have potential anti-trypanosomal activity in vitro. Also used as a reagent in the synthesis of (R)-(4-Nitrophenyl)oxirane (N504430) and (S)-(4-Nitrophenyl)oxirane (N504435).

정의

ChEBI: 4-nitroacetophenone is a member of the class of acetophenones that is acetophenone substituted at the para-position by a nitro group. It is a C-nitro compound and a member of acetophenones.

제조 방법

In the presence of catalyst cobalt stearate, p-nitroethylbenzene is oxidized to synthesize 4-nitroacetophenone with air at 140-150°C and 0.2MPa pressure. The reaction product is washed with water, neutralized, centrifugally dehydrated, and dried to obtain a finished product.

주요 응용

One of several alternative routes to synthetic chloroamphenicol uses 4-nitroacetophenone as starting material with a first-stage bromination to α-bromo-4-nitroacetophenone followed by buildup of the side chain. α-bromo-4-nitroacetophenone is the key precursor in the synthesis of the bronchodilator clenbuterol.

일반 설명

P-nitroacetophenone appears as yellow prisms or bright yellow powder. (NTP, 1992)

공기와 물의 반응

Insoluble in water.

반응 프로필

A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

화재위험

Flash point data for 4-Nitroacetophenone are not available. 4-Nitroacetophenone is probably combustible.

Purification Methods

Crystallise the ketone from EtOH or aqueous EtOH. [Beilstein 7 IV 657.]

4-Nitroacetophenone 준비 용품 및 원자재

원자재

p-니트로벤조일클로라이드 에틸벤젠 코발트 스테아르산염 4-Nitroethylbenzene p-Nitroethylbenzene 2-Ethylnitrobenzene 질산 수산화나트륨 황산

준비 용품

3-(4-니트로-페닐)-이속사졸-5-일라민 A-브로모-4-니트로아세토페논헥사민 DL-THREO-2-ACETAMIDO-L-(4-니트로페닐)-L,3-프로판디올 5-(4-니트로페닐)-2H-피라졸-3-일라민 클렌부테롤 4-(1,2,3-THIADIAZOL-4-YL)ANILINE 4-(4-니트로페닐)-1,2,3-티아디아졸 염화암페니콜 다이에톡시메테인 2-Ethylnitrobenzene 4-아미노-알파-tert-부틸아민-3,5-디클로로아세토페논 4'-AMINOBUTYROPHENONE p-아미노아세트페논 N-[1-(히드록시메틸)-2-(4-니트로페닐)-2-옥소에틸]아세트아미드 FGH-10019 2-메틸-2-(4-니트로페닐)-2-프로판올

4-Nitroacetophenone 공급 업체

글로벌( 369)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	997	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-18791163155 +86-13119157289	13119157289@163.com	China	2973	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2958	58

4-Nitroacetophenone 관련 검색:

p-메틸아세토페논 아세토페논 4'-히드록시아세토페논 P-클로로아세트페논 4'-메톡시아세토페논 p-아미노아세트페논 4'-Bromoacetophenone 3-Aminoacetophenone 4-Nitrobenzophenone 2-Nitroacetophenone p-Nitrophenylacetonitrile L-PICEIN 4-Nitrophenylacetic acid 3-Nitroacetophenone 4'-(Trifluoromethyl)acetophenone 4-NITROPHENYLACETYLENE 4-Nitrobenzyl alcohol 2-BROMO-2'-NITROACETOPHENONE