클로로메틸-2,2-디메틸프로피오네이트
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클로로메틸-2,2-디메틸프로피오네이트 속성
- 녹는점
- <-40°C
- 끓는 점
- 146-148 °C (lit.)
- 밀도
- 1.045 g/mL at 25 °C (lit.)
- 굴절률
- n
20/D 1.417(lit.)
- 인화점
- 104 °F
- 저장 조건
- Inert atmosphere,2-8°C
- 용해도
- 클로로포름(약간), 에틸아세테이트(적게)에 용해됨
- 물리적 상태
- 액체
- Specific Gravity
- 1.038
- 색상
- 무색투명~미황색
- 수용성
- 대부분의 유기용매와 섞일 수 있습니다. 물과 섞이지 않습니다.
- BRN
- 1560838
- InChIKey
- GGRHYQCXXYLUTL-UHFFFAOYSA-N
- CAS 데이터베이스
- 18997-19-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 10-20/21/22-36/37/38 | ||
| 안전지침서 | 16-26-36-41-36/37/39 | ||
| 유엔번호(UN No.) | UN 3272 3/PG 3 | ||
| WGK 독일 | 3 | ||
| TSCA | Yes | ||
| 위험 등급 | 3 | ||
| 포장분류 | III | ||
| HS 번호 | 29159000 | ||
| 기존화학 물질 | KE-11822 |
클로로메틸-2,2-디메틸프로피오네이트 C화학적 특성, 용도, 생산
화학적 성질
Clear colorless to slightly yellow liquid용도
Chloromethyl pivalate was used in the synthesis of pivaloyloxy methyl ester of ofloxacin as prodrug. It was used as the reagent during the synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis.주요 응용
Chloromethyl pivalate is a pharmaceutical intermediate compound used in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonomethoxyethyl)adenine. It is used as a protecting agent for the N-protection of amines. It is also used in the preparation of thivaloyloxymethyl ester of ofloxacin as a prodrug. It is also used in the preparation of sulbactam pivoxil by reaction with the sodium salt of sulbactam. Besides, it is used as a reagent in the synthesis of isoindoline cyclic and continuous flow organic synthesis.일반 설명
Chloromethyl pivalate reacts with sodium salt of sulbactam to yield sulbactam pivoxil. It undergoes acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to yield bis(pivaloyloxymethyl) PMEA.Synthesis
Chloromethyl pivalate is prepared by the reaction of formaldehyd and pivaloyl chloride. The specific synthesis steps are as follows:A mixture of pivaloyl chloride (8.56 g, 71 mmol), paraformaldehyde (2.13 g, 71 mmol) and zinc chloride (75 mg, 0.55 mmol) was stirred at 80 °C for 2 h. Purification by vacuum distillation afforded chloromethyl pivalate (41) as a colourless oil (6.29 g, 44.7 mmol, 59%). bp 80 °C/15 mmHg [lit.1 bp 80-81 °C/15 mmHg]; 1H NMR (400 MHz, CDCl3) δ 1.24 (9H, s, tBu), 5.72 (2H, s, CH2).
클로로메틸-2,2-디메틸프로피오네이트 준비 용품 및 원자재
원자재
준비 용품
피발로일록시메틸6-아미노노페니실라네이트
피발로일옥시메틸6-(페닐아세트아미도)페니실라네이트
(4-클로로-7H-피롤로[2,3-d]피리미딘-7-일)메틸피발레이트
Adefovir dipivoxil N6-Hydroxymethyl Impurity
Adefovir dipivoxil
1-(피발로일록시메틸)-1H-인돌-3-카르복실산
Azidomethyl pivalate
2,2-Dimethylpropanoic acid [[[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]phosphinylidene]bis(oxymethylene) ester
7-Hydroxy-6-methoxy-3-[(pivaloyloxy)methyl]-3,4-dihydroquinazolin-4-one
클로로메틸-2,2-디메틸프로피오네이트 공급 업체
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