2-Deoxy-D-glucose
2-Deoxy-D-glucose
- CAS:
- 154-17-6
- MF:
- C6H12O5
- MW:
- 164.16
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Properties
- Melting point:
- 146-147 °C(lit.)
- alpha
- 45.5 º (c=2, H2O)
- Boiling point:
- 211.61°C (rough estimate)
- Density
- 1.1738 (rough estimate)
- refractive index
- 46.5 ° (C=1, H2O)
- storage temp.
- 2-8°C
- solubility
- H2O: 50 mg/mL, clear, colorless to faintly yellow
- form
- crystalline
- pka
- pK1:12.52 (25°C)
- color
- white
- optical activity
- +38.5 → +45.9
- Water Solubility
- Soluble in water.
- Merck
- 14,2904
- BRN
- 1723331
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used within 1 working day.
- InChIKey
- PMMURAAUARKVCB-CEZCPVKQSA-N
- LogP
- -1.460 (est)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319
- Precautionary statements
- P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 24/25-37/39-36-26
- WGK Germany
- 3
- RTECS
- MQ3325000
- F
- 3-10
- TSCA
- Yes
- HS Code
- 29400090
Use
2-deoxy-D-Glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis. This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response. 2-deoxy-D-Glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models.[Cayman Chemical]
9 India supplier list of "2-Deoxy-D-glucose"
- Product Name:2-Deoxy-D-glucose
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:2-DEOXY-D-GLUCOSE
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:2-Deoxy-D-glucose
- Products Intro:Brand:sigma aldrich | Product Number:D3179 | Purity:BioXtra,≥98%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:2-Deoxy-D-glucose
- Company Type: Trader
- Country/Region: INDIA
- Product Name:2-Deoxy-D-glucose
- Products Intro:Brand:tcichemicals | Product Number:D0051 | Purity:min.97.0%(totalofisomers)
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:2-Deoxy-D-glucose
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:2-Deoxy-D-glucose
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:2-Deoxy-D-Glucose(2-DG)extrapureAR,99.9%
- Products Intro:Brand:trivenichemical | Product Number:43421
- Company Type: Trader
- Country/Region: INDIA
- Product Name:2-Deoxy-D-Glucose
- Products Intro:Brand:clearsynth | Product Number:CS-O-01387
- Company Type: Trader
- Country/Region: INDIA
- Product Name:2-Deoxy-D-glucose
- Company Type: Reagent
- Country/Region: INDIA