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3-hydroxyphenazepam
3-hydroxyphenazepam
- CAS:
- 70030-11-4
- MF:
- C15H10BrClN2O2
- MW:
- 365.61
Properties
- Boiling point:
- 544.5±50.0 °C(Predicted)
- Density
- 1.70±0.1 g/cm3(Predicted)
- storage temp.
- refrigerate for prolonged storage
- solubility
- DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.2 mg/ml
- form
- A neat solid
- pka
- 10.80±0.70(Predicted)
- color
- White powder
- Sensitive
- protect from strong sunlight.
Safety Information
Use
3-Hydroxyphenazepam, a metabolite of phenazepam, is also a GABAA receptor agonist. It has diminished myorelaxant properties, but is about equivalent in most other regards.Like other benzodiazepines, 3-hydroxyphenazepam behaves as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor with an EC50 value of 10.3 nM. 3-hydroxyphenazepam is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety.
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