6-Thioguanine
6-Thioguanine
- CAS:
- 154-42-7
- MF:
- C5H5N5S
- MW:
- 167.19
Suppliers by country/region
Company Type
Properties
- Melting point:
- ≥300 °C(lit.)
- Density
- 1.483 (estimate)
- refractive index
- 1.5605 (estimate)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water and in ethanol (96%). It dissolves in dilute solutions of alkali hydroxides.
- form
- lyophilized powder
- pka
- pKa 8.22 (Uncertain)
- Boiling point:
- 555.4±42.0 °C(Predicted)
- color
- Yellow to green
- Water Solubility
- soluble
- Merck
- 14,9337
- BRN
- 157765
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMF may be stored at -20°C for up to 1 month.
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301
- Precautionary statements
- P301+P310
- Hazard Codes
- T,Xi
- Risk Statements
- 25-23/24/25
- Safety Statements
- 28-36/37/39-45-28A
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- UP0740000
- F
- 13
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29335990
- Toxicity
- LD50 oral in mouse: 160mg/kg
Use
6-Thioguanine is a purine analogue structurally related to 6-mercaptopurine and azathioprine. Thioguanine interferes with several enzymes required for de novo purine synthesis, and its metabolites are incorporated into DNA and RNA, further impeding nucleic acid synthesis. The mechanism of action of thioguanine in psoriasis is not clearly understood; it has been hypothesized to affect the proliferation and trafficking of lymphocytes as well as the proliferation of keratinocytes.
4 India supplier list of "6-Thioguanine"
- Product Name:Thioguanine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:6-Thioguanine
- Products Intro:Brand:sigma aldrich | Product Number:A4660 | Purity:Hybri-Max?,50?×,γ-irradiated,lyophilizedpowder,BioXtra,suitableforhybridoma
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:6-Thioguanine,≥98%
- Products Intro:Brand:ottokemi | Product Number:T0184
- Company Type: Trader
- Country/Region: Mumbai,INDIA
- Product Name:Thioguanine(1660000)
- Products Intro:Brand:pharmaffiliates | Product Number:PAUSP1660000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:6-Thioguanine
- Products Intro:Brand:ajchemicals | Product Number:JDH-25154 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:2-amino-3,7-dihydropurine-6-thione
- Products Intro:Brand:thermofisher.in | Product Number:ALF-B21280-03 | Purity:98%
- Company Type: Trader
- Country/Region: Maharashtra,INDIA
- Product Name:2-Amino-6-mercaptopurine
- Products Intro:Brand:clearsynth | Product Number:CS-T-47883
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:6-Thioguanine
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:6-Thioguanine
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:6-Thioguanine
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA