Altretamine manufacturers and suppliers in india

Altretamine

Properties

Melting point:: 171-175 °C (lit.)

Boiling point:: 339.81°C (rough estimate)

Density: 1.0441 (rough estimate)

refractive index: 1.6100 (estimate)

storage temp.: Keep in dark place,Inert atmosphere,Room temperature

solubility: Chloroform (Sparingly), Methanol (Slightly, Heated)

form: solid

pka: pKa 10.3 (Uncertain)

color: White to Off-White

Water Solubility: Insoluble

Merck: 13,318

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 22-36/37/38

Safety Statements: 26-36

WGK Germany: 3

RTECS: OS1050000

HS Code: 2933690000

Toxicity: LD50 in rats, guinea pigs (mg/kg): 350, 255 orally (Jasper)

Use

Altretamine is available in 50-mg capsules for oraladministration as a second-line treatment for ovarian cancer.The mechanism of action has not been firmly established, althoughthe spectrum of activity is similar to that for otheralkylating agents; however, cross-resistance is not seen.Cytotoxicity has been correlated with metabolism to give thecarbinolamines, which may form imines capable of crosslinking,or decompose to give formaldehyde, which may reactwith nucleophiles on DNA or proteins. The agent is well absorbedupon oral administration, well distributed, and highly(90%) plasma protein bound. The agent is extensively metabolizedin the liver by CYP to give demethylated metabolites via the previously mentioned carbinolamines. Elimination occursprimarily in the urine as mostly demethylated metaboliteswith a terminal elimination half-life of 4 to 10 hours.Myleosuppression and nausea/vomiting are dose-limitingtoxicities. Other adverse effects include lethargy, agitation,hallucinations, skin rash, and elevations in transaminase levels,flulike symptoms, abdominal cramps, and diarrhea.