Cefuroxime manufacturers and suppliers in india

Cefuroxime

Properties

Melting point:: 171.5-173°C

alpha: D20 +63.7° (c = 1.0 in 0.2M pH 7 phosphate buffer)

Density: 1.76

refractive index: 1.6000 (estimate)

storage temp.: 2-8°C

solubility: DMSO (Slightly), Methanol (Slightly)

pka: pKa 2.5(H2O) (Uncertain)

form: Solid

color: White to Off-White

Water Solubility: 145mg/L at 25℃

BCS Class: 4

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H334-H317

Precautionary statements: P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501

Hazard Codes: Xn

Risk Statements: 42/43

Safety Statements: 22-24-37-45

WGK Germany: 3

RTECS: XI0329000

Use

Cefuroxime axetil (Ceftin) is the 1-acetyoxyethyl ester ofcefuroxime. During absorption, this acid-stable, lipophilic,oral prodrug derivative of cefuroxime is hydrolyzed to cefuroximeby intestinal and/or plasma enzymes. The axetilester provides an oral bioavailability of 35% to 50% of cefuroxime,depending on conditions. Oral absorption of theester is increased by food but decreased by antacids and histamineH2-antagonists. The latter effect may be because ofspontaneous hydrolysis of the ester in the intestine becauseof the higher pH created by these drugs. Axetil is used forthe oral treatment of non–life-threatening infections causedby bacteria that are susceptible to cefuroxime. The prodrugform permits twice-a-day dosing for such infections.