β-Estradiol
β-Estradiol
- CAS:
- 50-28-2
- MF:
- C18H24O2
- MW:
- 272.39
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Properties
- Melting point:
- 178-179 °C(lit.)
- Boiling point:
- 355.44°C (rough estimate)
- alpha
- D25 +76 to +83° (dioxane)
- Density
- 1.0708 (rough estimate)
- refractive index
- 80.4 ° (C=1, Dioxane)
- Flash point:
- 2℃
- storage temp.
- room temp
- solubility
- Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
- form
- powder
- pka
- pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)
- color
- White to off-white
- Water Solubility
- Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
- Merck
- 14,3703
- BRN
- 1914275
- BCS Class
- 1
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- VOXZDWNPVJITMN-ZBRFXRBCSA-N
Safety Information
- Symbol(GHS)
GHS08,GHS09
- Signal word
- Danger
- Hazard statements
- H351-H360FD-H362-H410
- Precautionary statements
- P202-P260-P263-P264-P273-P308+P313
- Hazard Codes
- T,Xn,F
- Risk Statements
- 60-61-45-63-64-40-36-20/21/22-11-48
- Safety Statements
- 53-22-36/37/39-45-36/37-26-16-36-20
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- KG2975000
- F
- 8-10
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29372390
- Toxicity
- LD50 subcutaneous in rat: > 300mg/kg
Use
β-Estradiol is an endogenous estrogenic hormone receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors. β-Estradiol is an activator of PI 3-kinase.Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
40 India supplier list of "β-Estradiol"
- Product Name:Estradiol
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: New Delhi,INDIA
- Product Name:Estradiol
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Estradiol
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Estradiol
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Estradiol (8R,9S,13S,14S,17S)-13-methyl-7,8,9,11,12,13,14,15,16,17 -decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
- Products Intro:Purity: 96% | Package: 25 mg, 50 mg , 100mg or 500 mg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Estradiol
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Madhya Pradesh,INDIA
- Product Name:Estradiol
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:17β-Estradiol-CAS50-28-2-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:3301 | Purity:Mostpotentmammalianestrogenichormone.
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Beta-estradiol 97%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.131183
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:β-Estradiol
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA