Itraconazole
Itraconazole
- CAS:
- 84625-61-6
- MF:
- C35H38Cl2N8O4
- MW:
- 705.63
Suppliers by country/region
- India(181)
- CHINA(283)
- United States(70)
- United Kingdom(24)
- Canada(12)
- Germany(8)
- Europe(3)
- Slovakia(1)
- France(3)
- Switzerland(4)
- South Korea(8)
- Mexico(2)
- Slovenia(1)
- Belgium(3)
- Colombia(1)
- Brazil(4)
- Austria(2)
- Japan(3)
- Poland(2)
- Italy(2)
- Nigeria(1)
- United Arab Emirates(1)
- Spain(2)
- Greece(1)
- Uruguay(1)
- Egypt(1)
- Malaysia(1)
- Nepal(1)
Company Type
Properties
- Melting point:
- 166°C
- alpha
- -0.1～+0.1°(D/20℃)(c=10,CH2Cl2)
- Boiling point:
- 850.0±75.0 °C(Predicted)
- Density
- 1.27 g/cm3
- Flash point:
- >110°(230°F)
- storage temp.
- 2-8°C
- solubility
- chloroform: 50 mg/mL, clear, colorless
- form
- White powder
- pka
- 3.7(at 25℃)
- color
- white
- Water Solubility
- Insoluble in water. Solube in chloroform at 50 mg/ml. Slightly soluble in ethanol or methanol
- Merck
- 14,5245
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- VHVPQPYKVGDNFY-UHFFFAOYSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
- Hazard Codes
- Xi,Xn,T,F
- Risk Statements
- 36/37/38-36/38-22-39/23/24/25-23/24/25-11
- Safety Statements
- 22-26-36-45-36/37-16
- RIDADR
- UN 3286 8(6.1)(3) / PGII
- WGK Germany
- 3
- RTECS
- XZ5481000
- HS Code
- 2934990002
- Toxicity
- LD50 (14 day) in mice, rats, dogs (mg/kg): >320, >320, >200 orally (Van Cauteren)
Use
The imidazole antifungal agents for the triazole ring, through inhibiting the activation of cytochrome P-450, including oxidase and peroxidase, disable the 14, α-methyl sterols to be dehydrogenated and be converted to ergosterol, so that the growth and proliferation of fungi are inhibited. They have strong lipophilicity and penetrate through the biofilm to inhibit the binding of the membrane to the fungus. The antibacterial spectrum is similar to ketoconazole. It is effective in the treatment of superficial fungal diseases such as vaginal and oral candidiasis as well as skin mycosis. Furthermore, it is expected to become the highly-efficient and safe drugs for the treatment of deep fungal infections such as cryptococcal encephalitis (AIDS). It is used for the treatment of vulvovaginal candidiasis, pityriasis and skin fungal disease pityriasis caused by sensitive fungi.
181 India supplier list of "Itraconazole"
- Product Name:Itraconazole
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Itraconazole
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:ITRACONAZOLE
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Itraconazole
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Itraconazole
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Itraconazole
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: New Delhi,INDIA
- Product Name:Itraconazole
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Itraconazole
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Itraconazole
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Uttar Pradesh,INDIA
- Product Name:Itraconazole- BP/USP/Ph. Eur
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA