Mitotan manufacturers and suppliers in india

Mitotan

Properties

Melting point:: 77-78 °C(lit.)

Boiling point:: 405.59°C (rough estimate)

Density: 1.3118 (rough estimate)

refractive index: 1.6000 (estimate)

storage temp.: Inert atmosphere,Room Temperature

solubility: DMSO: soluble20mg/mL, clear

form: powder

color: white to beige

Water Solubility: <0.1 g/100 mL at 24 ºC

Merck: 13,6237 / 13,6237

BRN: 2056007

InChI: InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H

InChIKey: JWBOIMRXGHLCPP-UHFFFAOYSA-N

SMILES: C1(Cl)=CC=CC=C1C(C1=CC=C(Cl)C=C1)C(Cl)Cl

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H351

Precautionary statements: P280

Hazard Codes: Xn

Risk Statements: 40

Safety Statements: 36/37

RIDADR: 3249

WGK Germany: 3

RTECS: KH7880000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 2903990002

Use

Mitotane is an inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells. It blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activity in human adrenocortical cells. Mitotane has anti-neoplastic actions, alone or in combination with other compounds, and suppresses cortisol synthesis, although it also has significant toxicity in the gastrointestinal tract and nervous system. It is effective against adrenocortical carcinoma and Cushing’s Syndrome in clinical trials.