PF 477736
PF 477736
- CAS:
- 952021-60-2
- MF:
- C22H25N7O2
- MW:
- 419.49
Suppliers by country/region
Company Type
Properties
- Density
- 1.56
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- pka
- 11.79±0.20(Predicted)
- color
- yellow
- InChIKey
- NDEXUOWTGYUVGA-LJQANCHMSA-N
Safety Information
- WGK Germany
- 3
Use
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA damage-induced cell cycle arrest, potentiating the antiproliferative effects of these compounds in tumor cell lines and xenografts.[Cayman Chemical]
1 India supplier list of "PF 477736"
- Product Name:PF-477736
- Products Intro:Brand:sigma aldrich | Product Number:PZ0186 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:PF0477736 >95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.089195
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:PF 477736
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:PF 477736
- Products Intro:Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL
- Product Name:PF 477736
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:PF-477736 PF477736
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: PF 477736
- Company Type: Trader
- Country/Region: CHINA
- Main Products: sarms
- Product Name:PF 477736
- Products Intro:Purity: 98% | Package: 1KG；10KG；100KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 5-Heptylresorcinol,Methyl 2-heptyl-4,6-dihydroxybenzoate,Cannabinoids Precursors,2,4-dihydroxy-6-propyl-benzoic acid methyl ester,Benzoic acid, 2-hexyl-4,6-dihydroxy-, methyl ester
- Product Name:PF 477736
- Products Intro:Purity: 0 | Package: 1g; 5g; 25g; 1kg; 5kg; 25kg | CustNote: 0
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical intermediate