Streptozotocin manufacturers and suppliers in india

Streptozotocin

Properties

Melting point:: 121 °C (dec.) (lit.)

alpha: D25 +39°

Boiling point:: 408.44°C (rough estimate)

Density: 1.4410 (rough estimate)

refractive index: 1.6500 (estimate)

storage temp.: -20°C

solubility: Soluble in DMSO (up to 25 mg/ml) or in Water (up to 25 mg/ml)

pka: pKa 1.3 (Uncertain)

form: powder

color: white to light yellow

Water Solubility: soluble

Sensitive: Hygroscopic

Merck: 13,8912

BRN: 2060675

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

InChIKey: ZSJLQEPLLKMAKR-FEQHFJGESA-N

Safety Information

Symbol(GHS): GHS02,GHS08

Signal word: Warning

Hazard statements: H228-H341-H351

Precautionary statements: P201-P202-P210-P240-P241-P308+P313

Hazard Codes: Xn,T

Risk Statements: 40-61-46-45-22-20/21/22

Safety Statements: 36/37-53-45-36-22

RIDADR: 3249

WGK Germany: 3

RTECS: LZ5775000

F: 3-10-21

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29419090

Toxicity: LD50 in female mice (mg/kg): 360 i.p.; 275 i.v.; in male dogs (mg/kg): 50 i.v. (Iwasaki)

Use

Streptozocin is a compound containing N-nitroso ,it acts as a nitric oxide donor in pancreatic islets ; it can induce the death of diabetic animal model style of insulin-secreting cells . Efficient DNA methylation agent, can induce chromosome breakage.it has cell toxicity On the neuroendocrine tumor cell lines with the expression of GLUT2 glucose transporter (GLUT2 glucose transporter) . Streptozocin is used for inducing Type 1 diabetes in Medical researches .