Tolnaftate manufacturers and suppliers in india

Tolnaftate

Properties

Melting point:: 110.5-111.5°C

Boiling point:: 453.4±38.0 °C(Predicted)

Density: 1.1328 (rough estimate)

refractive index: 1.6970 (estimate)

storage temp.: Sealed in dry,2-8°C

solubility: Soluble in chloroform at 50 mg/ml. Sparingly soluble in ethanol or methanol

form: powder

pka: -0.35±0.50(Predicted)

color: white to off-white

Water Solubility: <0.1 g/100 mL at 22 ºC

λmax: 258nm(MeOH)(lit.)

Merck: 14,9519

InChIKey: FUSNMLFNXJSCDI-UHFFFAOYSA-N

LogP: 5.142 (est)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P305+P351+P338

WGK Germany: 2

RTECS: FD8891300

TSCA: Yes

HazardClass: IRRITANT

HS Code: 2930206050

Toxicity: LD50 in mice, rats (g/kg): >10, >6 orally; >6, >4 s.c. (Hashimoto)

Use

O,2-Naphthyl m,N-dimethylthiocarbanilate (Tinactin,Aftate, NP-27) is a white crystalline solid that is insoluble inwater, sparingly soluble in alcohol, and soluble in most organicsolvents. The compound, a thioester of β-naphthol, isfungicidal against dermatophytes, such as Trichophyton,Microsporum, and Epidermophyton spp., that cause superficialtinea infections. Tolnaftate is available in a concentrationof 1% in creams, powders, aerosols, gels, and solutionsfor the treatment of ringworm, jock itch, and athlete’s foot.Tolnaftate has been shown to act as an inhibitor of squaleneepoxidase in susceptible fungi, so it is classified with theallylamine antimycotics. Tolnaftate is formulated into preparationsintended to be used with artificial fingernails to counteractthe increased chance of ringworm of the nail beds.